Words similar to polycystic
Example sentences for: polycystic
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Eighty-five families with at least two members with ruptured or unruptured IA and no family history of polycystic kidney disease were ascertained from a sampling frame of 1150 consecutive patients treated between 1977 and 1990 for aneurysmal SAH by the Department of Neurosurgery at the University Hospital of Kuopio, which serves a genetically homogenous population of 870,000 in eastern Finland [ 1 ] . Initially, family history was assessed by a short questionnaire and all putative cases were confirmed from medical and autopsy records.
Currently, several risk factors have been identified including cigarette smoking, arterial hypertension, gender, aging, atherosclerosis and heavy alcohol consumption [ 9 10 11 12 ] . Initial indications of a genetic component were based on collections of case reports that suggested that IAs are associated with some rare simple Mendelian disorders, e.g. autosomal dominant polycystic kidney disease, Ehlers Danlos syndrome type IV and the Marfan syndrome [ 13 ] . More recent systematic prevalence estimates indicate either absence of association or markedly reduced prevalence of IA among patients with rare simple Mendelian disorders [ 14 15 ] . Also, genetic analyses of genes known to cause some simple Mendelian disorders have proven negative for collections of patients with IA [ 16 17 ] . The familial occurrence of IAs not associated with known simple Mendelian disorders was first noted in 1942 [ 18 ] and, since then, nearly one hundred case reports and review articles have been published.
Upper-abdominal ultrasonography was performed on all screened individuals and confirmed that none of these individuals had evidence of polycystic kidney disease.
The ovaries of the αERKO female are consistently polycystic and lack evidence of spontaneous ovulation.
The clinical relevance is emphasized by our previous finding that the expression of GDF-9 is dysregulated in oocytes of women with Polycystic Ovary Syndrome [ 47 ] .
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