Words similar to polyarthritis
Example sentences for: polyarthritis
How can you use “polyarthritis” in a sentence? Here are some example sentences to help you improve your vocabulary:
Progression of established polyarthritis in the Tg197 hTNF-α transgenic mouse can be reversed by treatment with anti-TNF-α mAb, as shown by significant improvement in clinical and histological scores.
TTP-deficient mice exhibit cachexia, with dermatitis, medullary and extramedullary hyperplasia, erosive polyarthritis, and autoimmunity with autoantibodies [ 25 ] . This phenotype is similar to that observed in mice that overexpress TNF [ 26 ] . In agreement with these data, TTP-deficient mice were shown to overproduce TNF, and weekly injections of a neutralizing antibody to TNF eliminated the predominant features of this phenotype.
These results demonstrate that blocking hTNF-α reverses joint inflammation and promotes joint healing in this model of polyarthritis.
Tumor necrosis factor alpha (TNF-α) is elevated in sera and synovial fluid of patients with RA, suggesting that it may play a role in the pathology of the disease [ 4 ] . Soluble TNF-α receptor or neutralizing antibodies against TNF-α have been shown to prevent collagen-induced arthritis in mice [ 5 6 ] . Furthermore, a human TNF-α (hTNF-α) transgenic mouse (Tg197) develops a chronic, progressive polyarthritis with histologic features in common with RA [ 7 ] . Weight loss and joint swelling in these mice are correlated with expression of hTNF-α mRNA in the joints [ 7 ] and hTNF-α concentrations in the serum [ 8 9 ] . Previously, Keffer et al.
Amelioration of established polyarthritis by treatment with anti-TNF-α mAb
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