Words similar to pneumocystis
Example sentences for: pneumocystis
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Tat has been shown to down-regulate mannose receptor, EDF-1, CD3-gamma, and TCR/CD3 surface receptor [ 14 ] . Tat reduces mannose receptor levels and promoter activity in mature macrophages and dendritic cells by interfering with the host transcriptional machinery; resulting in decreased levels of surface mannose receptor needed for Ag (mannosylated albumin uptake) or pathogen capture (Pneumocystis carinii phagocytosis), and eventual delivery to MHC class II-containing intracellular compartments [ 15 ] . EDF-1, a gene down-regulated when endothelial cells are induced to differentiate in vitro , was shown to be down-regulated by Tat at the transcriptional level, resulting in the inhibition of endothelial cell growth and in the transition from a nonpolar cobblestone phenotype to a polar fibroblast-like phenotype [ 16 ] .
We have shown that α-actinin is abundant in the bone marrow stroma matrix, presumably at focal adhesion sites [ 5 ] . We have also reported that a 31 kDa amino-terminal α-actinin fragment, which we have named mactinin, is generated by the degradation of extracellular α-actinin by monocyte-secreted urokinase [ 6 ] . Furthermore, we have demonstrated that mactinin is present in inflammation caused by Pneumocystis carinii pneumonia, by examining bronchoalveolar lavage fluid from mice with infection [ 6 ] . It was not present in mice not challenged with P. carinii , suggesting that inflammaton is necessary for mactinin formation.
Antiretroviral therapy and Pneumocystis carinii pneumonia (PCP) prophylaxis have improved the clinical course and outcome of HIV-infected patients.
Pneumocystis carinii causes pneumonia in immunocompromised patients with a high morbidity and mortality rate.
Despite the relatively low sequence similarity to bacterial DHPS, all archaeal orthologs have the conserved catalytic residues identified in DHPS (Figure 2) and are confidently predicted, by the hybrid-fold-recognition method, to assume the same fold as DHPS from Pneumocystis carinii and Staphylococcus aureus whose crystal structures have been determined.
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