Words similar to pneumococci
Example sentences for: pneumococci
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Different serogroups have vastly different frequencies among pneumococci isolated from carriage [12,15,16,17] and otitis media [12,18]; for example, serogroups 4 and 18 and the non-vaccine serogroups are isolated far less commonly than several of the other pneumococcal types identified in Figure 1. One could postulate that these differences in frequency of carriage are offset by differences in immunogenicity; however, there is little evidence that serotypes 4 or 18C are more immunogenic than other, far more common serotypes [4,15].
Since most individuals do not suffer from invasive pneumococcal disease in this age range, carriage or mucosal disease (otitis media) from pneumococci may be the immunizing event for anticapsular antibodies in the general population [12] (although in principle immunity to some serogroups could be generated in response to cross-reacting antigens from other bacterial species or other sources [14]).
We have also shown that intranasal immunization with unencapsulated, killed pneumococci protects against nasopharyngeal colonization, in a fashion that is independent of antibody but requires CD4+ T cells at the time of challenge.
It would be unsurprising if different capsular types were differentially effective in permitting pneumococci to evade phagocytosis and other host defenses [31] (M.
We have recently shown that mice that are exposed thrice at weekly intervals to intranasal colonization with encapsulated pneumococci are protected against subsequent carriage, that this protection is effective for heterologous as well as homologous capsular types, and that it is effective even in MuMT mice, which lack the ability to produce antibodies (Malley R, Trzcinski K, Srivastava A, Thompson CM, Anderson PW, et al.
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