Words similar to pm-only
Example sentences for: pm-only
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The idea of using PM-only information is based on the following observations: MAS4 essentially discards the one-one correspondence between a PM and its MM partner (for details, see materials and methods on MAS4 algorithm for absolute analysis) and still gives satisfactory interpretation, which suggests the contribution of MM probes might be approximated in a nonspecific manner overall.
To investigate the relative performance of PM/MM versus PM-only designs, we exploited the model to estimate gene expression levels using only PM probes, and compared it to the MBEI using both PM and MM probes.
Figure 3shows the histogram and Figure 4the boxplot of correlations of θs estimated from the 20-probe difference model and θs estimated from the 10-probe difference model (a), the 20-probe PM-only model (b) and the 20-probe MM-only model (c).
The wide range of probe set behavior is best seen in the SN ratios in Figure 4. For these reasons, we believe that a safe way to proceed is to integrate the results from both PM-only and PM-MM methods.
If, for a probe set, a simplified model (PM-only, MM-only or 10-probe difference model) performs reasonably well, we expect its θ estimates to correlate with that from the 20-probe difference model.