Words similar to pi-

Example sentences for: pi-

How can you use “pi-” in a sentence? Here are some example sentences to help you improve your vocabulary:

Signaling by the IGF-IR has been studied in many different cell types and is important for proliferation, survival, motility, adhesion, transformation, tumor formation and metastasis [for reviews see refs [ 31 32 ] ]. The receptor can directly phosphorylate the insulin receptor substrate 1 (IRS-1) and Shc proteins in the intact cell causing activation of PI-3Kinase and ras signaling [ 33 ] . More recently, it has been shown that the IGF-IR signals via the Gβγ subunits of the heterotrimeric Gi complex to stimulate PI-3Kinase and ras, and also activates the JAK/Stat pathway to cause phosphorylation of Stat3 [ 34 35 ] .
However, unlike PI-3 kinases, PIKKs are not known to phosphorylate lipids but do possess protein kinase activity.
The results obtained with the dominant negative IGF-IR are identical to published results reintroducing PTEN, hence, inhibition of upstream PI-3Kinase signaling might be a useful approach for PTEN-deficient tumors.
Adenoviral expression of wild-type PTEN can inhibit U87 tumor growth indicating that elevated PI-3Kinase signaling is responsible for the increased proliferation and survival of these cells [ 47 54 ] . Our subsequent studies were designed to test whether interruption of an upstream growth factor signal would have the same growth inhibitory effect as reintroduction of PTEN.
Restoring PTEN protein or function to reduce PI-3Kinase signaling prevents tumor growth in animal models.