Words similar to pi-

Example sentences for: pi-

How can you use “pi-” in a sentence? Here are some example sentences to help you improve your vocabulary:

Many PH domain proteins bind with high affinity to specific phosphoinositides such as PI-4,5-P2, PI-3,4-P2 or PI-3,4,5-P3 which are generated by PI-3 kinase [ 28 ] . This relationship was reflected by the high correlation coefficient (0.
However, unlike PI-3 kinases, PIKKs are not known to phosphorylate lipids but do possess protein kinase activity.
Our results suggest that a therapeutic strategy to inhibit the upstream stimulus for PI-3Kinase through blockade of growth factor receptors may provide a workable alternative.
Signaling by the IGF-IR has been studied in many different cell types and is important for proliferation, survival, motility, adhesion, transformation, tumor formation and metastasis [for reviews see refs [ 31 32 ] ]. The receptor can directly phosphorylate the insulin receptor substrate 1 (IRS-1) and Shc proteins in the intact cell causing activation of PI-3Kinase and ras signaling [ 33 ] . More recently, it has been shown that the IGF-IR signals via the Gβγ subunits of the heterotrimeric Gi complex to stimulate PI-3Kinase and ras, and also activates the JAK/Stat pathway to cause phosphorylation of Stat3 [ 34 35 ] .
Elevated PI-3Kinase can be normalized by reintroduction of PTEN to reduce PIP3 levels, but it has not been shown that this effect can also be achieved by disruption of an upstream signal that stimulates PI-3Kinase activity.