Words similar to pi-
Example sentences for: pi-
How can you use “pi-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Elevated PI-3Kinase can be normalized by reintroduction of PTEN to reduce PIP3 levels, but it has not been shown that this effect can also be achieved by disruption of an upstream signal that stimulates PI-3Kinase activity.
PI-3Kinase activity is acutely regulated and a number of isoforms have been cloned that are activated in response to various stimuli [ 4 ] . The major phosphatidylinositol-3-phosphate phosphatase in cells is the tumor suppressor PTEN [ 5 6 ] . This protein has a tonic inhibitory effect on PI-3Kinase signaling by reversing the 3'-phosphorylation.
Our results suggest that a therapeutic strategy to inhibit the upstream stimulus for PI-3Kinase through blockade of growth factor receptors may provide a workable alternative.
Many PH domain proteins bind with high affinity to specific phosphoinositides such as PI-4,5-P2, PI-3,4-P2 or PI-3,4,5-P3 which are generated by PI-3 kinase [ 28 ] . This relationship was reflected by the high correlation coefficient (0.
PTEN is altered or deleted in many human cancers [ 7 8 9 10 ] . In-vitro, cells that are deficient in PTEN show elevated PI-3Kinase signaling [ 11 ] . Reintroduction of PTEN in a variety of cancer cells, including glioma, breast, bladder and ovarian cancer cells, causes G1 arrest, inhibits tumorigenesis, and promotes anoikis [ 12 13 14 ] . Mechanistically, Akt activity is decreased, cell motility is decreased, expression of two cyclin-dependent kinase inhibitors p27 and p21 is increased, cyclin D1 is down-regulated, Rb phosphorylation is inhibited, and signaling via Grb2/SOS is suppressed [ 11 15 ] . The link between PTEN and cell growth is underscored by genetic experiments in mice.
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