Words similar to pi-

Example sentences for: pi-

How can you use “pi-” in a sentence? Here are some example sentences to help you improve your vocabulary:

PTEN is altered or deleted in many human cancers [ 7 8 9 10 ] . In-vitro, cells that are deficient in PTEN show elevated PI-3Kinase signaling [ 11 ] . Reintroduction of PTEN in a variety of cancer cells, including glioma, breast, bladder and ovarian cancer cells, causes G1 arrest, inhibits tumorigenesis, and promotes anoikis [ 12 13 14 ] . Mechanistically, Akt activity is decreased, cell motility is decreased, expression of two cyclin-dependent kinase inhibitors p27 and p21 is increased, cyclin D1 is down-regulated, Rb phosphorylation is inhibited, and signaling via Grb2/SOS is suppressed [ 11 15 ] . The link between PTEN and cell growth is underscored by genetic experiments in mice.
The results obtained with the dominant negative IGF-IR are identical to published results reintroducing PTEN, hence, inhibition of upstream PI-3Kinase signaling might be a useful approach for PTEN-deficient tumors.
However, unlike PI-3 kinases, PIKKs are not known to phosphorylate lipids but do possess protein kinase activity.
Elevated PI-3Kinase can be normalized by reintroduction of PTEN to reduce PIP3 levels, but it has not been shown that this effect can also be achieved by disruption of an upstream signal that stimulates PI-3Kinase activity.
Rad3 is a member of the phosphoinositide 3-kinase related kinase (PIKK) family [ 31 ] . These proteins are large (> 200 kDa) and share a domain related to the catalytic domain of phosphoinositide 3-kinases (PI-3 kinases).