Words similar to phosphotyrosine
Example sentences for: phosphotyrosine
How can you use “phosphotyrosine” in a sentence? Here are some example sentences to help you improve your vocabulary:
It is hypothesized that trans-tyrosine phosphorylation of the EGFR creates protein phosphotyrosine binding sites that act as a surrogate scaffold for ERK activation [ 7 ] . Since ORs share many similarities with LPAR and β 2 -ARs in the way they activate the ERK pathway [ 9 15 ] , we chose to examine whether RTK transactivation occurs and is a necessary aspect of δ-opioid-mediated ERK activation.
IgM - immunoglobulin of the M isotype; ova - chicken ovalbumin; PY - phosphotyrosine; PLCγ2 - phospholipase C γ2; anti - antibody or antiserum generated against indicated antigen; RT-PCR - reverse transcriptase polymerase chain reaction; ICKA - immune-complex kinase assay; ITAM - immunoreceptor tyrosine-based activation motifs; SH2 and SH3 - Src homology domains 2 and 3; PBS - phosphate-buffered saline.
Expression of the Cas(SD) or the Src KM/Cas(SD), fusion did not result in any increase in total phosphotyrosine containing proteins nor in the tyrosine phosphorylation of the Cas SD (data not shown and see Fig.
By contrast, wild-type and mutant EGFRs containing the T790M mutation did not display a significant change in either phosphotyrosine induction or p-EGFR:t-EGFR ratios (Figure 4A and 4B).
Thus c-crk interacts constitutively with downstream effectors such as C3G via its SH3 domains, and interacts in a phosphotyrosine dependent fashion with tyrosine phosphorylated receptors using its SH2 domain [ 39 ] . To analyze downstream signals regulated by these adaptor proteins, investigators have developed methods that target them to distinct cellular membrane compartments by using heterologous targeting sequences.
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