Example sentences for: phosphoproteins

How can you use “phosphoproteins” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The dephosphorylation of phosphoproteins is universally catalyzed by protein phosphatases that are classified into two major functional groups, protein tyrosine phosphatase (PTP) and protein serine/threonine phosphatase (PP) although enzymes with various degrees of dual-specificity are also encountered [ 1 2 3 4 5 ] . The majority of Ser/Thr phosphatases belong to three classical groups, namely PP1, PP2A, and PP2B (calcineurin), and possess similar primary structures in their catalytic cores [ 2 3 6 ] . PP1, in particular, exhibits an extremely high degree of sequence conservation through evolution, and its orthologs and isoforms are found in all eukaryotic cells [ 6 7 ] . In various organisms, PP1 regulates such diverse cellular processes as cell cycle progression, protein synthesis, carbohydrate metabolism, transcription, and neuronal signaling [ 3 7 ] , underscoring its profound importance in biology.

  • Like other steroid hormone receptors, GRs are phosphoproteins, and reversible phosphorylation of specific ser/thr residues on the GR or associated proteins has been implicated in the regulation of 1) hormone binding to the cytoplasmic GR-complex, 2) the translocation of the GR between the cytoplasm and the nucleus, 3) the binding of ligand activated GR to consensus GRE in the promoter regions of GR-responsive genes, and 4) the formation of an active transcriptional complex [ 1, 2, 5, 6, 7, 8, 28, 29, 30, 31].

  • All NFAT proteins except NFAT5 exist as phosphoproteins and are maintained in the cytoplasm of resting cells [ 2, 3, 11, 12].

  • Objects in nuclei recognized by antibodies specific for phosphoprotein epitopes, cytoplasmic IFs, or both, have been reported in glial and neuronal cells, in situ and in vitro . The nuclear structures appear spherical or rod-like and may have a positional relationship with nuclear pores [ 1 2 3 4 ] . Morphologically, these structures appear similar to the nuclear "speckles" that are thought to be storage sites for RNA splicing factors [ 5 6 7 ] . However, while intermediate filament (IF) phosphoproteins could be components of nuclear speckles, they are immunologically distinct.

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