Words similar to phosphoprotein
Example sentences for: phosphoprotein
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On the basis of sequence homo logy and similarity of three-dimensional structures, phosphoprotein phosphatases (PPases) have been classified into three families designated PPP, PPM, and PTP [reviewed in [ 1 2 3 ] . The PPP and PPM families are comprised of phosphoserine- and phosphothreonine-specific enzymes whereas the PTP family consists of phosphotyrosine-specific and dual-specificity enzymes [ 4 ] . The major members of the PPP family are PP1, PP2A, and PP2B (calcineurin) class of phosphatases.
The RNA genome of RSV is about 15 kb long and contains 11 documented protein-coding genes [ 13 ] . Three viral proteins are minimally required to reconstitute the functional transcription complex of NNR viruses [ 3 ] : the nucleocapsid protein (N) that wraps the negative-strand genome RNA and its full-length complement, the positive-strand antigenome RNA, thus converting them into highly nuclease-resistant, chromatin-like templates; the large protein (L), which is the major subunit of the RdRP; and the phosphoprotein (P), which is the smaller subunit of RdRP and an essential transcription factor of L [ 19 20 21 22 ] . In RSV, optimal transcription, although not replication, additionally requires the transcription antitermination protein M2-1 [ 13 ] . In addition, cellular actin, and to a lesser extent, profilin, are also required for viral transcription [ 17 18 ] .
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) or acidic ribosomal phosphoprotein (ARP) were used as internal controls.
RSV is a member of the Pneumovirus genus in the Paramyxoviridae family, and contains a nonsegmented negative-stranded RNA genome of about 15 kb [ 5 ] . The minimal viral RNA-dependent RNA polymerase (RdRP) consists of two virally encoded proteins, the large protein L and the phosphoprotein P [ 6 7 8 ] , and a third viral protein, M2-1 (22K), contributes RNA antitermination function and optimal processivity [ 9 ] . In addition to these viral proteins, the RdRP also requires cellular actin.
Preparation of phosphoprotein substrates
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