Words similar to phosphoprotein
Example sentences for: phosphoprotein
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Objects in nuclei recognized by antibodies specific for phosphoprotein epitopes, cytoplasmic IFs, or both, have been reported in glial and neuronal cells, in situ and in vitro . The nuclear structures appear spherical or rod-like and may have a positional relationship with nuclear pores [ 1 2 3 4 ] . Morphologically, these structures appear similar to the nuclear "speckles" that are thought to be storage sites for RNA splicing factors [ 5 6 7 ] . However, while intermediate filament (IF) phosphoproteins could be components of nuclear speckles, they are immunologically distinct.
The BRCA1 gene encodes a 220-kDa nuclear phosphoprotein that is regulated in response to DNA damaging agents [ 5, 6, 7] and in response to estrogen-induced growth [ 8, 9, 10, 11].
The activity of the catalytic subunit of PP1 is controlled by its interaction with a large number of regulatory subunits, many of which also target it to specific subcellular compartments [ 7 24 33 ] . The major ones include the glycogen-targeting subunits (G M , G L ) [ 34 ] , myofibrillar-targeting subunit (M 110 ) [ 34 ] , nuclear inhibitor of PP1 (NIPP-1) [ 35 ] , PP1 nuclear targeting subunit (PNUTS) [ 36 37 ] , mitosis-regulating subunit Sds22 [ 38 39 40 ] , ribosomal protein L5 [ 41 ] and small cytosolic inhibitory proteins, I-1, I-2, and DARRP-32 (Dopamine and cAMP-regulated phosphoprotein, Mr 32,000) [ 7 23 25 ] . The physiological role of many of these interactions has been revealed in recent studies.
We have also shown that recombinant NFATp purified from insect cells is a phosphoprotein that exhibits association with nuclei in vitro only after dephosphorylation by calcineurin.
RSV is a member of the Pneumovirus genus in the Paramyxoviridae family, and contains a nonsegmented negative-stranded RNA genome of about 15 kb [ 5 ] . The minimal viral RNA-dependent RNA polymerase (RdRP) consists of two virally encoded proteins, the large protein L and the phosphoprotein P [ 6 7 8 ] , and a third viral protein, M2-1 (22K), contributes RNA antitermination function and optimal processivity [ 9 ] . In addition to these viral proteins, the RdRP also requires cellular actin.
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