Example sentences for: phenobarbital

How can you use “phenobarbital” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Under the Oregon Death With Dignity Act you must consult with a physician and a psychiatric counselor before imbibing the $45 cup of hemlock (actually Phenobarbital D).

  • Initial results showed that CAR is an apparently constitutive transactivator able to activate gene expression in the absence of exogenously added ligands [ 8 9 ] . The first CAR ligands identified, androstanol and androstenol, are inverse agonists that block this constitutive transactivation [ 10 ] . More recently, it has been found that CAR mediates the characteristic response of a subset of drug metabolizing enzymes to a variety of structurally unrelated foreign compounds [ 11 ] . These xenobiotic activators are referred to as "phenobarbital (PB) - like," based on the prototypic effects of the anti-epileptic agent on drug metabolism [ 12 13 14 ] . The most potent activator of murine CAR is the high affinity agonist ligand TCPOBOP (1,4-bis [2-(3,5-dichloropyridyloxy)]benzene) [ 15 16 ] .

  • Febrile seizures are the most prevalent type of seizures experienced by children, affecting up to 5% of the world's population [ 1 ] . Although most febrile seizures are benign and do not require treatment, they are distressing to parents, and in a few circumstances, can increase the risk of subsequent epilepsy [ 2 ] . In clinical practice, therapy for febrile seizures presently is unsatisfactory, since clinical data are insufficient to document efficacy of most anti-epileptic drugs [ 3 ] . The most commonly used drug, phenobarbital, has significant deleterious effects on learning and behavior.

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