Words similar to pharmacokinetic
Example sentences for: pharmacokinetic
How can you use “pharmacokinetic” in a sentence? Here are some example sentences to help you improve your vocabulary:
PKQuest is a new generic "physiologically based pharmacokinetic model" (PBPK) [ 1 ] . A PBPK provides an approach to modeling drug distribution and metabolism that is based on the use of a physiologically realistic model of the animal.
One limitation of our study was that no pharmacokinetic analyses were performed to validate whether the RTV dosage regimen co-administered with APV600 was effectively boosting plasma APV exposure or C min levels.
To reduce APV pill burden and possibly improve tolerability of APV treatment, pharmacokinetic research efforts have been directed at combining APV with the PI ritonavir (RTV), which inhibits CYP3A4-mediated hepatic metabolism of APV, thereby enhancing plasma APV exposure [ 13 14 15 ] . The administration of RTV at the clinically sub-therapeutic dosage of 100 mg BID was found to boost APV plasma exposure to such a degree as to permit halving the APV daily pill burden from 16 to 8 capsules/day, in addition to maintaining the minimum plasma APV concentration (C min ) over 24 hours well above the 50% inhibitory concentrations (IC 50 ) of patient-derived HIV-1 isolates [ 15 ] . A pharmacokinetic study in 20 HIV-infected patients, PROF1004, showed that APV at the lower dosage of 600 mg BID combined with RTV 100 mg BID (APV600/RTV) resulted in a geometric mean steady-state APV C min (1.
Currently, five PPIs are marketed: rabeprazole, omeprazole, esomeprazole, lansoprazole and pantoprazole, each with a different pharmacokinetic profile, tissue selectivity, binding specificity and potential to interact with the cytochrome P450 enzyme system [ 8 9 10 ] . For example, rabeprazole and esomeprazole achieve more rapid and profound inhibition of acid secretion than do older agents [ 10 ] . It is unclear, however, if these pharmacologic differences lead to distinctions in the clinical efficacy of healing gastric ulcers and controlling ulcer symptoms.
These assumptions are eliminated in PKQuest [ 5 ] , a new, general-purpose physiologically based pharmacokinetic (PBPK) software routine.
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