Words similar to pharmacokinetic
Example sentences for: pharmacokinetic
How can you use “pharmacokinetic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Experimental pharmacokinetic data
These assumptions are eliminated in PKQuest [ 5 ] , a new, general-purpose physiologically based pharmacokinetic (PBPK) software routine.
To reduce APV pill burden and possibly improve tolerability of APV treatment, pharmacokinetic research efforts have been directed at combining APV with the PI ritonavir (RTV), which inhibits CYP3A4-mediated hepatic metabolism of APV, thereby enhancing plasma APV exposure [ 13 14 15 ] . The administration of RTV at the clinically sub-therapeutic dosage of 100 mg BID was found to boost APV plasma exposure to such a degree as to permit halving the APV daily pill burden from 16 to 8 capsules/day, in addition to maintaining the minimum plasma APV concentration (C min ) over 24 hours well above the 50% inhibitory concentrations (IC 50 ) of patient-derived HIV-1 isolates [ 15 ] . A pharmacokinetic study in 20 HIV-infected patients, PROF1004, showed that APV at the lower dosage of 600 mg BID combined with RTV 100 mg BID (APV600/RTV) resulted in a geometric mean steady-state APV C min (1.
Since the above pharmacokinetic studies and others involving pharmacokinetic modeling predictions were conducted over only a short period (generally ≤ 14 days) and in a small number of patients, there remained a need to evaluate low-dose APV/RTV combinations in large populations of HIV-1-infected patients over a therapeutically relevant period.
Secreted vector encoded proteins are not suitable to interpret the early manifestation of transgene expression, as plasma levels are highly dependent on the pharmacokinetic properties of the encoded proteins.
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