Example sentences for: pharmacokinetic

How can you use “pharmacokinetic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This result is consistent with the fact that a 2-exponential function is used in most of the recent experimental applications of deconvolution [ 18 33 34 ] . For the more "complicated" pharmacokinetic PBPK model where there is extensive tissue binding (similar to that for propranolol), a 2-exponential function fit is no longer adequate (fig.

  • These assumptions are eliminated in PKQuest [ 5 ] , a new, general-purpose physiologically based pharmacokinetic (PBPK) software routine.

  • Currently, five PPIs are marketed: rabeprazole, omeprazole, esomeprazole, lansoprazole and pantoprazole, each with a different pharmacokinetic profile, tissue selectivity, binding specificity and potential to interact with the cytochrome P450 enzyme system [ 8 9 10 ] . For example, rabeprazole and esomeprazole achieve more rapid and profound inhibition of acid secretion than do older agents [ 10 ] . It is unclear, however, if these pharmacologic differences lead to distinctions in the clinical efficacy of healing gastric ulcers and controlling ulcer symptoms.

  • Experimental pharmacokinetic data

  • The greater magnitude of virologic suppression in the study population as a whole with the APV600/RTV regimen was expected in view of the results of earlier clinical pharmacokinetic studies showing a >6-fold higher C min level with APV600/RTV BID compared with the APV1200 BID regimen [ 16 ] . Higher C min values achieved with RTV-boosting may be critical in treating antiretroviral-experienced patients, particularly those with HIV isolates having increased IC 50 values.


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