Words similar to pharmacokinetic
Example sentences for: pharmacokinetic
How can you use “pharmacokinetic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Candidates with the best predictions were submitted for further evaluation of their pharmacokinetic parameters.
To reduce APV pill burden and possibly improve tolerability of APV treatment, pharmacokinetic research efforts have been directed at combining APV with the PI ritonavir (RTV), which inhibits CYP3A4-mediated hepatic metabolism of APV, thereby enhancing plasma APV exposure [ 13 14 15 ] . The administration of RTV at the clinically sub-therapeutic dosage of 100 mg BID was found to boost APV plasma exposure to such a degree as to permit halving the APV daily pill burden from 16 to 8 capsules/day, in addition to maintaining the minimum plasma APV concentration (C min ) over 24 hours well above the 50% inhibitory concentrations (IC 50 ) of patient-derived HIV-1 isolates [ 15 ] . A pharmacokinetic study in 20 HIV-infected patients, PROF1004, showed that APV at the lower dosage of 600 mg BID combined with RTV 100 mg BID (APV600/RTV) resulted in a geometric mean steady-state APV C min (1.
Their main partner in this effort is the National Institute of Allergy and Infectious Diseases, which has provided support for pharmacokinetic and toxicology studies by virtue of pre-existing contracts with SRI International (an independent nonprofit research-and-development organization) in Menlo Park, California, United States.
One limitation of our study was that no pharmacokinetic analyses were performed to validate whether the RTV dosage regimen co-administered with APV600 was effectively boosting plasma APV exposure or C min levels.
Secreted vector encoded proteins are not suitable to interpret the early manifestation of transgene expression, as plasma levels are highly dependent on the pharmacokinetic properties of the encoded proteins.
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