Words similar to pericentric

Example sentences for: pericentric

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We next investigated the nature of the sequence underlying the pericentric inversion breakpoint by extracting the 1 Mb interval encompassing the sequence between the most distal PTR XVp probe, RP11-360J18, and the most proximal PTR XVq probe, RP11-736I24, from the November 2002 human genome assembly.
Using a panel of FISH probes spanning several known sites of rearrangement within 15q11-q13 we were able to narrow the region containing the PTR pericentric inversion breakpoint to a complex cluster of segmental duplications approximately 600 kb in length, according to the most recent assembly of the human genome.
This reinforces the view that there may be functional differences in arm and pericentric cohesion and perhaps different mechanisms to load cohesin, as has been proposed for cohesin on meiotic chromosomes for
Upon hybridization of this probe to a panel of human, pygmy chimpanzee, common chimpanzee and gorilla genomic DNAs, two bands were observed in the human sample and a single band was noted in all great ape species, providing further evidence that the CHRNA7 duplication was specific to humans and was not present at the time of the pericentric inversion event in the chimpanzee genome.
The association of two independent chromosomal rearrangement events at one site: a pericentric inversion in the chimpanzee genome, and the insertion of a novel segmental duplication within the human lineage, may be a consequence of the overall genomic instability of this region.