Words similar to pericentric
Example sentences for: pericentric
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Another important difference between cohesin binding along arms and at centromeres is that the arm sites do not appear to be dependent on a DNA consensus sequence, whereas binding to pericentric regions requires specific centromere sequence [13,14].
Using a panel of FISH probes spanning several known sites of rearrangement within 15q11-q13 we were able to narrow the region containing the PTR pericentric inversion breakpoint to a complex cluster of segmental duplications approximately 600 kb in length, according to the most recent assembly of the human genome.
Large-scale sequence analysis of this region between human and chimpanzee will be necessary to refine the exact position of the pericentric inversion.
Upon hybridization of this probe to a panel of human, pygmy chimpanzee, common chimpanzee and gorilla genomic DNAs, two bands were observed in the human sample and a single band was noted in all great ape species, providing further evidence that the CHRNA7 duplication was specific to humans and was not present at the time of the pericentric inversion event in the chimpanzee genome.
Our FISH results using probe RP11-40J8, which demonstrated dual signals on PTR XVp and XVq, indicated we had reached the site of the pericentric inversion, or alternatively a sequence within RP11-40J8 had been duplicated to both arms of PTR XV.