Words similar to pericentric
Example sentences for: pericentric
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Recent studies have characterized several evolutionary breakpoints in common chimpanzee and other great ape species including pericentric inversions and a chromosome translocation [ 7 8 9 ] . We present here a refinement of the breakpoint associated with a previously identified pericentric inversion of the human 15q11-q13 orthologous region in common chimpanzee (XVp) to a region containing multiple segmental duplications [ 1 2 10 ] .
This reinforces the view that there may be functional differences in arm and pericentric cohesion and perhaps different mechanisms to load cohesin, as has been proposed for cohesin on meiotic chromosomes for
Another important difference between cohesin binding along arms and at centromeres is that the arm sites do not appear to be dependent on a DNA consensus sequence, whereas binding to pericentric regions requires specific centromere sequence [13,14].
Using a panel of FISH probes spanning several known sites of rearrangement within 15q11-q13 we were able to narrow the region containing the PTR pericentric inversion breakpoint to a complex cluster of segmental duplications approximately 600 kb in length, according to the most recent assembly of the human genome.
, cohesin at centromeric and pericentric domains is spread over a broad region (up to 50 kb), large quantities of the protein complex are bound, and binding is not affected by the natural transcriptional and coding status of the regions that are occupied.