Words similar to pericentric
Example sentences for: pericentric
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Upon hybridization of this probe to a panel of human, pygmy chimpanzee, common chimpanzee and gorilla genomic DNAs, two bands were observed in the human sample and a single band was noted in all great ape species, providing further evidence that the CHRNA7 duplication was specific to humans and was not present at the time of the pericentric inversion event in the chimpanzee genome.
With our results indicating the CHRNA7 sequence is single copy in the chimpanzee genome and thus unlikely to be involved in the inversion, the GLP/LCR15 duplicon is therefore the best candidate sequence for being present at the site of the pericentric inversion.
It has been shown in multiple studies that regions of segmental duplication can be associated with evolutionary rearrangements [ 8 29 ] . The pericentric inversion of chimpanzee XVp, having been localized to a site of multiple segmental duplications in the human genome, indicates that the evolutionary rearrangement is likely to involve such sequences.
Recent studies have characterized several evolutionary breakpoints in common chimpanzee and other great ape species including pericentric inversions and a chromosome translocation [ 7 8 9 ] . We present here a refinement of the breakpoint associated with a previously identified pericentric inversion of the human 15q11-q13 orthologous region in common chimpanzee (XVp) to a region containing multiple segmental duplications [ 1 2 10 ] .
Previous cytogenetic analyses of human, chimpanzee, gorilla and orangutan G-banded metaphase chromosomes demonstrated that the pericentric inversion was a chimpanzee-specific event, with humans maintaining the ancestral state of this region when compared to gorilla and orangutan [ 1 2 ] . Two-color FISH experiments utilizing distal probe RP11-88O16, and the PWS/AS common deletion breakpoint-marking probe pDJ-778A2 clearly show that the chimpanzee lineage is the sole great ape species to harbor this rearrangement (Figure 2).
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