Example sentences for: pedf-receptor

How can you use “pedf-receptor” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The fact that the binding of PEDF to cell surfaces decreases with heparin/HS depletion, implies that heparin/HS molecules might act as cofactors for PEDF-receptor interactions.

  • The fact that depletion of heparin/HS-like GAGs from the culturing media results in inhibition of PEDF binding to cell surface receptors points to functional roles for these GAGs such as those of positive modulators of PEDF-receptor interactions.

  • Note that with the binding method used, the amount of 125I-PEDF retained in CM without cells is the same to the amount of non-specific 125I-PEDF binding (reactions with cells and in the presence of 50-fold molar excess of unlabeled PEDF) [ 18 ] , indicating retention by PEI-treated glass-fiber filters of PEDF-receptor or GAG-PEDF-receptor complexes rather than PEDF-GAG.

  • GAG-binding proteins can be differentially sensitive to variations in GAG structure [ 27 ] . GAGs produced among different cell types have structural and compositional differences and structural changes in GAGs are known to occur in cells undergoing morphological differentiation and/or malignant transformations [ 28 29 30 31 ] . Thus, in the native retina, or other tissue, modulation of the PEDF-receptor interactions may depend on the expression of GAGs, which occur during development and pathological conditions.

  • These observations showed that a component(s) secreted by retinoblastoma cells enhanced the PEDF-receptor interactions.

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