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Example sentences for: pedf

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PEDF, pigment epithelium-derived factor; GAG, glycosaminoglycan; HS, heparan sulfate; CM, media conditioned by retinoblastoma cells.
It has been proposed that the GAG-binding property of PEDF provides the molecular basis for its association with extracellular matrices and may serve to localize PEDF activity in the retina and CNS [ 14 19 ] . However, the present results point to direct effects these polysaccharides might have on the biochemical interactions between PEDF and PEDF receptors on the surfaces of cells that respond to this neurotrophic factor.
Because binding of cell-surface receptors to polyethylenimine filters is rather insensitive to ionic strength, the ionic phenomenon is thought to be supplemented by hydrophobic forces and hydrogen binding [ 32 ] . The method used with Y-79 cells and radiolabeled PEDF has been described before in detail [ 18 ] . Briefly, cells cultured overnight in serum-deprived medium at 37°C were transferred to ice/water bath for 10 minutes before the addition of ligand.
The binding of GAGs to PEDF that modulate the binding of these factors to its receptor opens also the possibility that different GAGs may modulate differently the affinity of PEDF for its receptors, by increasing or even decreasing it in some cases.
Biochemically, PEDF is a 50-kDa glycoprotein with structural homology to members of the serine-protease inhibitor (serpin) superfamily [ 3 15 ] . However, it has no inhibitory effects on proteases.