Words similar to pedf

Example sentences for: pedf

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The ratio and amount of production of heparin and HS by cells bearing PEDF receptors may be an important mechanism to control the activity of PEDF as is the modulation of the rate of expression of PEDF receptors.
The differentiation and survival of cells in vivo may be regulated not only by the expression of PEDF and its receptor but also by the temporal and spatial expression of GAGs.
It has been proposed that the GAG-binding property of PEDF provides the molecular basis for its association with extracellular matrices and may serve to localize PEDF activity in the retina and CNS [ 14 19 ] . However, the present results point to direct effects these polysaccharides might have on the biochemical interactions between PEDF and PEDF receptors on the surfaces of cells that respond to this neurotrophic factor.
The fact that the binding of PEDF to cell surfaces decreases with heparin/HS depletion, implies that heparin/HS molecules might act as cofactors for PEDF-receptor interactions.
PEDF binding to cell-surface receptors was assayed using biologically active radioligand 125I-PEDF and Y-79 cells [ 18 ] by a widely-used method with a mechanism of retention of receptors on polyethylenimine-treated glass-fiber filters based mainly on ionic interactions [ 32 ] . Polyethylenimine binds strongly to glass, which is negatively charged and integral membrane proteins tend to be acidic.