Example sentences for: pedf

How can you use “pedf” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In a spatial structure of PEDF, the heparin/HS binding domain of PEDF maps to the opposite side of the neurotrophic active region [ 20 ] , allowing distinct and non-overlapping interactions with heparin/HS on one side of the protein, and with the neurotrophic receptor on its opposite side.

  • PEDF also has binding affinity for GAGs, such as, heparin, heparin- and chondroitin-sulfates, but this affinity is ~1000-fold lower than for the receptor (e.g.

  • Its neurotrophic activities are independent of its protease inhibition potential but dependent on its interaction with cell-surface receptors [ 9 12 16 17 18 ] . PEDF has high binding affinity for cell-surface receptors in human retinoblastoma Y-79 cells (K

  • PEDF binding to cell-surface receptors was assayed using biologically active radioligand 125I-PEDF and Y-79 cells [ 18 ] by a widely-used method with a mechanism of retention of receptors on polyethylenimine-treated glass-fiber filters based mainly on ionic interactions [ 32 ] . Polyethylenimine binds strongly to glass, which is negatively charged and integral membrane proteins tend to be acidic.

  • Finally, the fact that the GAG and receptor binding regions are on opposite regions of the PEDF molecule, suggest the possibility of the existence of PEDF mutants or engineered variants that, having lost or decreased GAG-binding capabilities, still show high affinity for the PEDF receptor in a way not dependent upon GAGs content or composition.


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