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Example sentences for: peaking
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Among genes that are stimulated by FSH/cAMP during the period of maturation of Sertoli cells (15 to 20 days of age in rats), are several subunits of cAMP-dependent protein kinase (PKA), the serine/threonine kinase mainly responsible for the downstream effects of FSH [ 15 ] . Expression of the RIIβ regulatory subunit of cAMP-dependent protein kinase is highly induced (50-fold) at the mRNA level in primary cultures of rat Sertoli cells as a late response to cAMP peaking at 12 hours [ 16 ] . We have demonstrated that expression of CAAT/Enhancer binding protein β (C/EBPβ) is induced by cAMP with rapid kinetics in Sertoli cells, and that C/EBPβ is responsible for induction of late response genes like the RIIβ-gene [ 17 ] . The RIIβ promoter contains a conserved E-box/HLH element in the basal promoter localized at -280 to -275 relative to the functional ATG [ 18 ] . This element is shown to be important for cAMP-responsiveness in granulosa cells, and it has been shown to bind both USF and Myc in CHO and NB2a cells [ 18 19 ] . In this work, we show that USF isoforms may regulate cAMP responsiveness of the RIIβ promoter by modulating the effect of C/EBP, and that the formation of USF isoforms may be regulated by cAMP in Sertoli cells.
The film is based on a book by Joe Connelly, who cruised the streets of Manhattan in an ambulance from the mid-'80s to the early '90s, when the crack epidemic was peaking and New York had become the embodiment of everything untenable about major American cities.
NewsHour's Mark Shields says that Bradley aides are actually worried about peaking too soon.
However, the authors warned that the high percentage of HCoV-NL63-positive samples could be due to a strong viral activity in the study year, and long-term studies are needed to determine whether HCoV-NL63 infections occur in cycles peaking every two to three years, as observed for other respiratory viruses.
Remarkably, resistin levels rose dramatically because of endotoxemia, peaking 8–16 h after LPS administration (Figure 5A).
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