Words similar to parathyroid
Example sentences for: parathyroid
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Familial hyperparathyroidism may be confined to parathyroid adenoma (HRPT1 #145000) or may involve the broader endocrine disturbances of multiple endocrine neoplasia Types I (#131100) and IIA (#171400).
Intestinal calcium absorption is increased after feeding a low calcium diet or under conditions of increased calcium needs, such as during growth, via a parathyroid hormone (PTH)-vitamin D mediated process [ 3 ] . A lowering of serum calcium levels stimulates the secretion of PTH that then activates the renal conversion of inactive 25-hydroxyvitamin D to the active hormonal metabolite 1,25-dihydroxyvitamin D. At the intestine, 1,25-dihydroxyvitamin D, acting through a nuclear receptor, stimulates transcription of vitamin D-mediated genes, including calbindin D, involved in calcium transport thereby acting as the primary hormonal regulator of active intestinal calcium transport [ 3 ] . It is thus likely that any putative key molecular player in calcium absorption, such as CaT1 or ECaC1, should be a prime target for hormonal regulation by 1,25-dihydroxyvitamin D. However, to date, neither CaT1 nor ECaC1 expression has been shown to be related to serum 1,25-dihydroxyvitamin D or vitamin D status [ 10 16 ] .
BTBD1 and BTBD2 cDNA were found in libraries from the following tissues: amniotic, aorta, bone, brain, bone marrow, colon, ear, embryo, foreskin, gall bladder, germ, heart, kidney, lung, muscle, ovary, pancreas, parathyroid, placenta, skin, spleen, stomach, testis, thymus, tonsil and uterus (LocusID 53339 and 55643, respectively [ 22 ] ). BTBD1 and BTBD2 was also expressed in a large number of tumor types and normal tissues present in SAGE (serial analysis of gene expression) libraries (SAGEmap, [ 23 ] ).
The only bone anabolic agent known to increase bone mineral density in both animal models and clinical settings is human parathyroid hormone 1-34 (PTH), which has recently been approved by the FDA in patients with advance osteoporosis [ 10 ] . Bone-related basic and clinical research has been searching intensively for alternative anabolic agents for the treatment of osteoporosis.
Laboratory studies are shown in Table 1. The intact parathyroid hormone (PTH) was appropriately suppressed to 6 pg/mL with concomitant serum calcium of 13.