Words similar to paramutation
Example sentences for: paramutation
How can you use “paramutation” in a sentence? Here are some example sentences to help you improve your vocabulary:
These repeats are often part of the trans-silencer locus or paramutagenic locus or its target [ 10 14 15 16 17 ] . However, the repeat can sometimes be located at a considerable distance from the affected locus itself, as has recently been shown for the single-copy maize b1 gene [ 18 ] . Other than transcriptional gene silencing, paramutation is only weakly correlated with DNA methylation.
Paramutation has been studied extensively for four maize loci that encode transcriptional regulators of pigment biosynthesis [ 1 ] . Paramutation has also been investigated in the Arabidopsis PAI gene family, at the a1 and chalcone synthase (CHS) transgene loci in petunia, and in a number of other cases [ 2 3 4 ] . The Arabidopsis resistance gene BAL/CPR1 displays a related form of epigenetic instability [ 5 6 ] . Interactions resembling paramutation also occur among non-allelic transgene loci with DNA sequence homology.
In these cases one master locus tends to suppress the expression of its target locus ('trans-silencing') [ 7 8 9 10 11 ] . Paramutation and trans-silencing are related processes.
Epigenetic activity, defined here as partnership in heritable trans-silencing or paramutation, is not predictable from the DNA sequence alone, and its molecular basis is incompletely understood.
Whether the imprint imposed by a paramutagenic locus is relayed effectively from the first target locus to a secondary target locus is a variable characteristic of paramutation systems, and this has implications for the speed of epiallele conversion within outcrossing populations.
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