Example sentences for: paramutation

How can you use “paramutation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Paramutation has been studied extensively for four maize loci that encode transcriptional regulators of pigment biosynthesis [ 1 ] . Paramutation has also been investigated in the Arabidopsis PAI gene family, at the a1 and chalcone synthase (CHS) transgene loci in petunia, and in a number of other cases [ 2 3 4 ] . The Arabidopsis resistance gene BAL/CPR1 displays a related form of epigenetic instability [ 5 6 ] . Interactions resembling paramutation also occur among non-allelic transgene loci with DNA sequence homology.

  • These data suggest that the competence for trans-silencing may be transferred between non-allelic transgenes, reminiscent of the allelic transfer of epigenetic activity during paramutation.

  • In these cases one master locus tends to suppress the expression of its target locus ('trans-silencing') [ 7 8 9 10 11 ] . Paramutation and trans-silencing are related processes.

  • These results underscore the similarity between trans-silencing and paramutation, because in both cases epialleles are often silenced incompletely and may also adopt novel regulatory patterns [ 4 10 ] , for example light inducibility [ 33 ] . Perhaps, silencing at the dimeric E82 locus involves a hierarchical relationship between its two intact T-DNAs.

  • Epigenetic activity, defined here as partnership in heritable trans-silencing or paramutation, is not predictable from the DNA sequence alone, and its molecular basis is incompletely understood.


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