Example sentences for: paracrine

How can you use “paracrine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Because SC were occasionally found juxtaposed to developing follicles, blood vessels and secondary interstitial cells, one cannot exclude the possibility that the SC-derived BMPs may have paracrine functions.

  • Very little is known about the role of the TE in folliculogenesis: however this new finding raises the possibility that BMP-3b and -4 could have autocrine actions on TE histogenesis and/or paracrine actions on theca/follicle morphogenesis.

  • These peptides are released into the central circulation and may act systemically, as opposed to many of the known mediators of sepsis, which are released locally and often act in an autocrine or paracrine fashion.

  • Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine factor produced primarily by mesenchymal cells.

  • The concept of lung fibroblasts as effector cells in the pathogenesis of idiopathic pulmonary fibrosis (IPF) has recently evolved [ 1 2 ] . Lung fibroblasts respond, in vitro , to inflammatory cytokines by producing growth factors and collagen, resulting in fibroblast proliferation and extracellular matrix deposition [ 2 3 4 ] . In addition, activated lung fibroblasts have been shown to produce large amounts of inflammatory cytokines and chemokines, in vitro , and hence, these cells may also have a role as effector-inflammatory cells [ 1 2 ] . This capacity to produce both inflammatory and fibrotic factors could mean that phenotypically altered lung fibroblasts act simultaneously as effector and target cells, via paracrine and autocrine mechanisms, perpetuating the fibrotic process [ 2 ] .


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