Example sentences for: paracrine

How can you use “paracrine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • [ 22 ] showed that SCYA17 potentially played a role via a paracrine mechanism in the development of allergic respiratory diseases.

  • Less obvious abnormalities in ciliary body tissues may also affect IOP by altering the volume or composition of the aqueous humor produced and possibly by altering the drainage structures in a paracrine fashion [ 42 ] . Thus, more subtle metabolic abnormalities in the ciliary body may interact with the iridocorneal angle phenotypic variation and contribute to variability in IOP elevation between human patients.

  • The concept of lung fibroblasts as effector cells in the pathogenesis of idiopathic pulmonary fibrosis (IPF) has recently evolved [ 1 2 ] . Lung fibroblasts respond, in vitro , to inflammatory cytokines by producing growth factors and collagen, resulting in fibroblast proliferation and extracellular matrix deposition [ 2 3 4 ] . In addition, activated lung fibroblasts have been shown to produce large amounts of inflammatory cytokines and chemokines, in vitro , and hence, these cells may also have a role as effector-inflammatory cells [ 1 2 ] . This capacity to produce both inflammatory and fibrotic factors could mean that phenotypically altered lung fibroblasts act simultaneously as effector and target cells, via paracrine and autocrine mechanisms, perpetuating the fibrotic process [ 2 ] .

  • Because SC were occasionally found juxtaposed to developing follicles, blood vessels and secondary interstitial cells, one cannot exclude the possibility that the SC-derived BMPs may have paracrine functions.

  • OPG is currently hypothesized to be an important paracrine mediator of the antiresorptive action of estrogen on bone cells [ 25].


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