Example sentences for: paracrine

How can you use “paracrine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The concept of lung fibroblasts as effector cells in the pathogenesis of idiopathic pulmonary fibrosis (IPF) has recently evolved [ 1 2 ] . Lung fibroblasts respond, in vitro , to inflammatory cytokines by producing growth factors and collagen, resulting in fibroblast proliferation and extracellular matrix deposition [ 2 3 4 ] . In addition, activated lung fibroblasts have been shown to produce large amounts of inflammatory cytokines and chemokines, in vitro , and hence, these cells may also have a role as effector-inflammatory cells [ 1 2 ] . This capacity to produce both inflammatory and fibrotic factors could mean that phenotypically altered lung fibroblasts act simultaneously as effector and target cells, via paracrine and autocrine mechanisms, perpetuating the fibrotic process [ 2 ] .

  • Various cytokines are also produced by biliary epithelial cells [ 14 ] . As biliary epithelial cells are capable of both producing and responding to cytokines, these cells may use cytokines for the autocrine/paracrine regulation of their own function as well as that of other cells.

  • Very little is known about the role of the TE in folliculogenesis: however this new finding raises the possibility that BMP-3b and -4 could have autocrine actions on TE histogenesis and/or paracrine actions on theca/follicle morphogenesis.

  • Because SC were occasionally found juxtaposed to developing follicles, blood vessels and secondary interstitial cells, one cannot exclude the possibility that the SC-derived BMPs may have paracrine functions.

  • , which is responsive to polycyclic ligands present in environmental toxicants) in promoting apoptosis during fetal oogenesis has recently been identified in mice [ 43 44 ] . Prospective endocrine/paracrine modifiers (which are altered by nutritional regimen) of the fates of fetal germ cells include glucocorticoids, thyroid hormones, insulin, growth hormone, insulin-like growth factors, and leptin [ 1 45 ] .


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