Words similar to paracortical

Example sentences for: paracortical

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Antigen-specific T cells encounter antigen presented by dendritic cells that migrate to the paracortical regions of draining lymph nodes after initial antigen contact [ 1 ] . Only dendritic cells have the capacity to induce activation in resting peripheral T cells [ 2 3 ] . Once activated, differentiated T helper cells contact antigen-specific B cells and provide signals for B cell differentiation via CD154-CD40 interactions, as well as by the production of cytokines [ 4 5 6 ] . Consistent with this general understanding of the induction of antibody responses to protein immunogens, good antibody responses to synthetic peptide-epitope constructs have been shown to depend on the presence, orientation, and multiplicity of the T cell epitope in the construct [ 7 8 9 10 11 ] . As a confirmation of this finding with synthetic epitope constructs, most protein immunogens studied to date contain multiple T cell epitopes, for example [ 12 13 ] .
This may specifically occur in the paracortical regions of lymph nodes, without further progression of the tolerized T cells into lymph node follicles.
Similarly, in lymph nodes and Peyer's patches, the wild-type and Ad-transduced transgenic T cells localized primarily to paracortical T cell areas.