Words similar to papillomavirus
Example sentences for: papillomavirus
How can you use “papillomavirus” in a sentence? Here are some example sentences to help you improve your vocabulary:
sunlight, human papillomavirus infection).
Converging evidence from epidemiological and molecular studies suggests that infection of genital human papillomavirus (HPV) is causally linked to the development of CC [ 4 ] . Since only a small fraction of HPV-infected cervical intra-epithelial neoplastic (CIN) lesions progress to invasive cancer, these studies further suggest that in addition to HPV, other host genetic factors play a role in cervical carcinogenesis [ 5 ] . A number of molecular studies have identified genetic alterations in these two histologic types of CC and at various stages of precursor lesions [ 6 7 8 ] . Despite this molecular characterization, the genetic basis of CC initiation and progression is still very poorly understood.
Formalin-fixed paraffin-embedded (FFPE) human papillomavirus (HPV) positive cell-lines (SiHa, HeLa and CaSki,) as well as FFPE cervical lesions (pre-invasive and invasive) infected with HPV have been used as model systems.
These include, PDCD6 , a protein that plays a role in T cell receptor-, FAS-, and glucocorticoid-induced cell death [ 11 ] ; TERT , a gene that encodes a reverse transcriptase component of telomerase, dysfunction of which promotes chromosomal instability [ 12 ] ; and TRIP13 , a thyroid hormone receptor interacting protein that binds with the human papillomavirus type 16 (HPV16) E1 protein [ 13 ] . We have identified POLS gene that encodes a DNA polymerase sigma, and plays a role in DNA replication and sister chromatid cohesion at the proximal minimal deleted region [ 14 ] . We performed a semi-quantitative RT-PCR analysis of all four genes ( PDCD6 , TERT , TRIP13 , and POLS ) in eight CC cell lines and did not find evidence for lack of or down regulated expression compared to normal cervix (Fig.
Recently, it has been shown that the hTERT amplification and over expression is common in CC [ 19 ] . TRIP13 , thyroid receptor interacting protein 13, is a transcription factor that regulates expression of a variety of specific target genes including the human papillomavirus type 16 (HPV16) E1 protein [ 13 ] . Similar to TERT , the TRIP13 also showed very low expression in normal cervix and highly elevated levels of expression in CC cell lines (Fig.
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