Words similar to papain-like
Example sentences for: papain-like
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This suggests that despite the absence of significant sequence similarity, the NlpC/P60 domain is likely to contain a structural core corresponding to the classical papain-like protease fold (Figure 2).
A comparison of the predicted secondary structure for this superfamily with known peptidase folds revealed that these three residues show exactly the same arrangement as the catalytic triad of papain-like thiol peptidases.
In the case of papain-like proteases - calpains, transglutaminases and NH 2 -acetyltransferases - the three-stranded sheet of the core is incorporated into β-barrel with five to eight constituent strands (Figure 2).
The presence of an analogous situation in the transglutaminases [ 30, 45] and the related NH 2 -acyltransferases [ 46] suggests that diverse acetyl/acyltransferase activities have been repeatedly derived in course of the evolution of the papain-like fold.
The observation that the three-stranded unit of the NlpC/P60 domain is followed by two other β-strands, suggests that the NlpC/P60 proteins are likely to form a five-stranded barrel similar to that seen in papain-like proteases (Figures 1, 2).
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