Example sentences for: papain-like

How can you use “papain-like” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The configuration, comprising a catalytic cysteine at the amino terminus of a helix packed against a core three-stranded β-sheet, with the second and third strands bearing the catalytic histidine and its orienting polar partner, is seen in the transglutaminases and a related class of amino-group acetyltransferases, papain-like proteases, adenoviral proteases and ubiquitin carboxy-terminal hydrolases [ 32, 38] (Figure 2).

  • However, in the NlpC/P60 domain, the distance between the helix bearing the catalytic cysteine and the core barrel is similar to that seen in the transglutaminases and NH 2 -aminotransferases, suggesting that it lacks the large insert that is seen in several papain-like proteases (Figure 2).

  • This suggests that despite the absence of significant sequence similarity, the NlpC/P60 domain is likely to contain a structural core corresponding to the classical papain-like protease fold (Figure 2).

  • The observation that the three-stranded unit of the NlpC/P60 domain is followed by two other β-strands, suggests that the NlpC/P60 proteins are likely to form a five-stranded barrel similar to that seen in papain-like proteases (Figures 1, 2).

  • Such substitutions have previously been observed in other papain-like peptidases with the serine participating in a functional active site [ 61, 62].


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