Example sentences for: papain-like

How can you use “papain-like” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The configuration, comprising a catalytic cysteine at the amino terminus of a helix packed against a core three-stranded β-sheet, with the second and third strands bearing the catalytic histidine and its orienting polar partner, is seen in the transglutaminases and a related class of amino-group acetyltransferases, papain-like proteases, adenoviral proteases and ubiquitin carboxy-terminal hydrolases [ 32, 38] (Figure 2).

  • A comparison of the predicted secondary structure for this superfamily with known peptidase folds revealed that these three residues show exactly the same arrangement as the catalytic triad of papain-like thiol peptidases.

  • However, in the NlpC/P60 domain, the distance between the helix bearing the catalytic cysteine and the core barrel is similar to that seen in the transglutaminases and NH 2 -aminotransferases, suggesting that it lacks the large insert that is seen in several papain-like proteases (Figure 2).

  • In the case of papain-like proteases - calpains, transglutaminases and NH 2 -acetyltransferases - the three-stranded sheet of the core is incorporated into β-barrel with five to eight constituent strands (Figure 2).

  • This difference may also explain the failure of sequence-structure threading algorithms, such as the combined fold prediction and 3DPSSM [ 39], to recover any significant hits to the papain-like proteases.

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