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Example sentences for: pand

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Individual SCF Pop1pand SCF Pop2pcomplexes bearing ubiquitin ligase activity
These data indicate that Pop1p and Pop2p assume their subcellular localization pattern independent of each other, indicating the possibility of distinct nuclear and cytoplasmic homooligomeric SCF Pop1pand SCF Pop2pcomplexes.
These findings indicate the existence of distinct SCF Pop1pand SCF Pop2pcomplexes in vivo .
In addition, based on overexpression, distinct SCF Pop1pand SCF Pop2pcomplexes were proposed to target unknown substrates, but no biochemical evidence of their activity was provided [ 18 ] . To address these questions, we cloned two additional subunits of SCF Popand performed a detailed characterization of its activity in vitro and in vivo . Our results indicate that heterooligomeric SCF Pop1p-Pop2pmediates Rum1p ubiquitylation whereas distinct SCF Pop1pand SCF Pop2pcomplexes target unknown nuclear and cytoplasmic substrates, thereby generating combinatorial diversity of SCF function in fission yeast.
In addition, compartmentalization of homooligomeric SCF Pop1pand SCF Pop2pcomplexes may direct the ubiquitylation of unknown nuclear and cytoplasmic substrates.