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On the other hand, Ovchinnikov et al.
One explanation for this sequence structure is that the transcripts were polyadenylated at the same location, and the polyadenylation signal mutated beyond recognition after the insertion event occurred; interestingly, Ovchinnikov et al . reported that polyadenylation signals tend to degrade rapidly after L1 insertion [ 44 ] . A second explanation is that the poly(A) sequence is encoded in DNA and either the transcript was degraded up to the position of the A-rich sequence or RNA polymerase II failed to elongate the message past the A-rich sequence; the resulting transcript would then resemble one that had been polyadenylated.
A similar sequence structure was reported by Ovchinnikov et al . for a 3'-transduction event [ 44 ] . Several possible explanations for this sequence structure are addressed in the Discussion.
One explanation given by Ovchinnikov et al . [ 44 ] is that the transcripts may have been internally primed at an A-rich sequence (see Additional data file and [ 44 ] ); a different type of internal priming is also required by a current model for 5' inversion of L1s [ 45 ] .
Interestingly, a recently proposed mechanism of 5' inversion of L1 elements requires that first-strand cDNA synthesis be primed internally on the L1 transcript [ 45 ] . Therefore, it is possible that the cDNA synthesis of a 3'-transducing transcript may also be primed at an internal A-rich site as suggested by Ovchinnikov et al . [ 44 ] (see Additional data file).