Example sentences for: outbred

How can you use “outbred” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • While analysts have predicted that very high polymorphism densities will be required for association mapping in mixed or outbred populations [see for example reference [ 7 ] ], promising results have been obtained using genome scans of 600-1200 STRPs in isolated populations where levels of linkage disequilibrium are particularly high [ 8 9 10 ] . In this manuscript we describe the development of two new 10 cM human STRP Screening Sets (Sets 12 and 52) which when combined provide average STRP spacing of 4.8 cM.

  • The SHR strain was derived by selective inbreeding from the Kyoto outbred Wistar colony, and both SHR and SHRSP, as well as WKY strains have been maintained over many generations through brother-sister matings http://rgd.mcw.edu/tools/strains [ 43 44 ] . Healthy WKA and GH rat strains were also generated from outbred Wistar rat strains, but these strains were isolated independently in Japan and New Zealand, respectively (and maintained at other sites as well).

  • Other investigators described differences of the same order of magnitude between mouse strains in expression of transgenes encoding α1-antitrypsin [ 1 ] , interleukin-12 [ 2 ] , and human endostatin [ 3 ] . These differences in transgene expression between inbred species may have clinical implications, as differences between inbred strains are considered to reflect differences between individuals of an outbred species.

  • Second, tissues may derive from individuals from different ethnic backgrounds; humans are highly outbred, leading to the potential of significant polymorphic noise (herein called "SNP noise") between individuals unrelated to the disease or variable under study.

  • A skin air sac model was used to compare the virulence of isolate CS101 and paired isogenic mutants [ 9 ] . Briefly an air- and liquid-tight connective tissue pouch was generated on the back of female, six week old, outbred CD1 mice (Charles River, Portage, MI) by slow dermal injection of 0.9 mL of air via an 0.4 mm needle on a 1.0 mL syringe.


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