Words similar to outbred
Example sentences for: outbred
How can you use “outbred” in a sentence? Here are some example sentences to help you improve your vocabulary:
A skin air sac model was used to compare the virulence of isolate CS101 and paired isogenic mutants [ 9 ] . Briefly an air- and liquid-tight connective tissue pouch was generated on the back of female, six week old, outbred CD1 mice (Charles River, Portage, MI) by slow dermal injection of 0.9 mL of air via an 0.4 mm needle on a 1.0 mL syringe.
The SHR strain was derived by selective inbreeding from the Kyoto outbred Wistar colony, and both SHR and SHRSP, as well as WKY strains have been maintained over many generations through brother-sister matings http://rgd.mcw.edu/tools/strains [ 43 44 ] . Healthy WKA and GH rat strains were also generated from outbred Wistar rat strains, but these strains were isolated independently in Japan and New Zealand, respectively (and maintained at other sites as well).
Consistent with this interpretation, Eggan et al have recently shown that viable offspring are more efficiently produced through tetraploid-mediated cloning from outbred ES cell line compared to inbred ES cell lines [ 14 ] . We, therefore, believed it likely that aggregation-compatible hprt negative ES cells could be generated by targeted mutation of the hprt gene in R1 ES cells.
Second, tissues may derive from individuals from different ethnic backgrounds; humans are highly outbred, leading to the potential of significant polymorphic noise (herein called "SNP noise") between individuals unrelated to the disease or variable under study.
Other investigators described differences of the same order of magnitude between mouse strains in expression of transgenes encoding α1-antitrypsin [ 1 ] , interleukin-12 [ 2 ] , and human endostatin [ 3 ] . These differences in transgene expression between inbred species may have clinical implications, as differences between inbred strains are considered to reflect differences between individuals of an outbred species.
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