Example sentences for: orthosteric

How can you use “orthosteric” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These putative endogenous Smo modulators could represent orthosteric or allosteric ligands.

  • In addition to the binding sites for natural or endogenous agonists (orthosteric sites), many GPCRs have also been found to have allosteric sites [ 35 ] . These sites can bind natural ligands, as in the case of Zn ions and heparin for the dopamine and neurokinin receptors, respectively, or bind synthetic drugs such gallamine, in the case of the muscarinic receptors [ 35 ] . Binding of small molecules to these allosteric sites can modulate activity of a receptor without directly mimicking or competing out the interaction of ligands to the orthosteric sites.


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