Example sentences for: orc

How can you use “orc” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This requires an alternative replication factor C (RF-C) complex [26,27,28] and may require the origin recognition complex (ORC) [29].

  • Thus it is possible that ORC binding is an aspect of enhancer function conserved from fission yeast to animals.

  • One of the hallmarks of yeast ORC binding to yeast ARS consensus sequences is its ATP dependence [ 6 ] . We were interested to see whether the DNA binding activity of the ~35 kDa protein is ATP dependent or not.

  • In eukaryotic DNA replication, sequence specific ATP dependent DNA binding activity has been demonstrated in yeast S. cerevisiae where ORC, a six polypeptide complex binds to yeast ARS consensus sequence in an ATP dependent manner [ 6 ] . The binding sites for other ORCs are not very clear at present.

  • In S. cerevisiae , ARS elements have been implicated to be important both for ORC binding and origin function [ 6 ] . We looked for the availability of such sequences in known human origins of replication like c-myc, lamin beta 2 and Dnmt1.


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