Example sentences for: orc

How can you use “orc” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These may be binding sites for the S. pombe Origin Recognition Complex (ORC), whose fourth largest subunit (Orp4) contains a multiple AT-hook domain, which permits it to bind with high affinity to DNA containing runs of adenines or thymines in one strand [ 14, 15].

  • It has recently been demonstrated that the Drosophila amplification enhancers, ACE3 and AER-d , bind Drosophila ORC [ 19].

  • In S. cerevisiae , ARS elements have been implicated to be important both for ORC binding and origin function [ 6 ] . We looked for the availability of such sequences in known human origins of replication like c-myc, lamin beta 2 and Dnmt1.

  • DmORC binds the critical elements of well-characterized, chromosome III amplification domain (ACE3 and ori-β, though the precise sequence recognized by DmORC within ACE3 and ori-β have not been identified [ 9 ] . Studies of both ScORC [ 19 ] and DmORC [ 20 ] indicate the ATP binding by Orc1p is required for DNA binding.

  • In fact, the largest subunit of S. pombe ORC (Orp1) has been mapped by chromatin immunoprecipitation to ars3002 and also to ars2004 , which, like ars3002 , contains multiple asymmetric A+T-rich stretches [ 16, 17].


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