Words similar to orc
Example sentences for: orc
How can you use “orc” in a sentence? Here are some example sentences to help you improve your vocabulary:
In fact, the largest subunit of S. pombe ORC (Orp1) has been mapped by chromatin immunoprecipitation to ars3002 and also to ars2004 , which, like ars3002 , contains multiple asymmetric A+T-rich stretches [ 16, 17].
This requires an alternative replication factor C (RF-C) complex [26,27,28] and may require the origin recognition complex (ORC) [29].
Chromatin immunoprecipitation (ChIP) studies have demonstrated the association of SpORC with S. pombe origins [ 21 ] and human ORC with the EBV Ori P [ 22 23 24 ] . Whether ORC binds to these sequences directly or indirectly with the help of other proteins are subject to in vitro DNA binding assays using purified ORC proteins.
In eukaryotic DNA replication, sequence specific ATP dependent DNA binding activity has been demonstrated in yeast S. cerevisiae where ORC, a six polypeptide complex binds to yeast ARS consensus sequence in an ATP dependent manner [ 6 ] . The binding sites for other ORCs are not very clear at present.
Note that all three of the consensus sequences and also many additional regions within the enhancer contain runs of adenines or thymines and thus are potential binding sites for S. pombe ORC.