Words similar to oligoclonality
Example sentences for: oligoclonality
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However, recent studies have indicated that large numbers of virus-specific CD8 +T cells preferentially accumulate in the synovial fluid of RA patients and that these cells are also oligoclonal, suggesting that non-antigen-specific homing may be responsible for the observed oligoclonality of CD8 +T cells in the synovial fluid [ 6 ] . Because chemokines such as macrophage inflammatory protein-1α and RANTES (regulated upon activation, normal T-cell expressed and secreted) are expressed in RA synovial tissue [ 7 8 ] , subsets of CD8 +T cells may be preferentially recruited into the synovial tissue in a non-antigen-specific manner.
In these analyses, virtually all V H families demonstrated extensive B-cell oligoclonality.
Further studies indicated that CD8 +T cells exhibit oligoclonality in the peripheral blood [ 3 4 ] and synovial fluid of RA patients [ 5 ] , raising the question of whether this oligoclonality is antigen driven.
We believe that in the instance illustrated in Figure 1the latter possibility is more likely, because the small V H 2 and V H 5 families (only two gene members per family) do not exhibit the same degree of oligoclonality as that observed with the only somewhat smaller V H 6 family (one gene member).
For example, flow cytometric analyses of circulating B cells [ 13] suggested that oligoclonality exists, and cell culture experiments [ 14, 15, 16, 17] demonstrated that synovial tissue explants spontaneously secrete immunoglobulins of restricted heterogeneity as defined by immunoglobulin (Ig)G subclass, isoelectric focusing, and idiotype expression.
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