Words similar to oligoclonality
Example sentences for: oligoclonality
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However, recent studies have indicated that large numbers of virus-specific CD8 +T cells preferentially accumulate in the synovial fluid of RA patients and that these cells are also oligoclonal, suggesting that non-antigen-specific homing may be responsible for the observed oligoclonality of CD8 +T cells in the synovial fluid [ 6 ] . Because chemokines such as macrophage inflammatory protein-1α and RANTES (regulated upon activation, normal T-cell expressed and secreted) are expressed in RA synovial tissue [ 7 8 ] , subsets of CD8 +T cells may be preferentially recruited into the synovial tissue in a non-antigen-specific manner.
Further studies indicated that CD8 +T cells exhibit oligoclonality in the peripheral blood [ 3 4 ] and synovial fluid of RA patients [ 5 ] , raising the question of whether this oligoclonality is antigen driven.
In these analyses, virtually all V H families demonstrated extensive B-cell oligoclonality.
For example, flow cytometric analyses of circulating B cells [ 13] suggested that oligoclonality exists, and cell culture experiments [ 14, 15, 16, 17] demonstrated that synovial tissue explants spontaneously secrete immunoglobulins of restricted heterogeneity as defined by immunoglobulin (Ig)G subclass, isoelectric focusing, and idiotype expression.
We believe that in the instance illustrated in Figure 1the latter possibility is more likely, because the small V H 2 and V H 5 families (only two gene members per family) do not exhibit the same degree of oligoclonality as that observed with the only somewhat smaller V H 6 family (one gene member).
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