Words similar to oh-dg

Example sentences for: oh-dg

How can you use “oh-dg” in a sentence? Here are some example sentences to help you improve your vocabulary:

This enzyme is the major repair enzyme involved in the defense against accumulation of the 8-OH-dG adducts discussed above.
In a study published after this report was submitted, an increased number of 8-OH-dG positive islet cells in human type 2 diabetic subjects was observed [ 32 ] . The staining was found to be mainly nuclear in contrast to the cytoplasmic Ogg1 staining found in the present report.
Unfortunately, we were unable to obtain specific staining with antibodies to 8-OH-dG.
In light of the previous publication on the role of 8-OH-dG adducts in a rat model of type 2 diabetes [ 31 ] , and the finding that the Ogg1 gene was over-expressed in human type 2 diabetes, we evaluated the expression of Ogg1 protein in pancreas specimens from type 2 diabetic and healthy subjects, as a marker for β-cell oxidative DNA damage in type 2 diabetes.
Ogg1 knockout mice possess increased levels of 8-OH-dG in their genome, particularly in the mitochondrial genome, but do not seem to exhibit an increased frequency of malignancies [ 44 45 46 ] . It was postulated that the consequences of 8-OH-dG adducts and Ogg1 deficiency affects mainly cells with high oxygen metabolism and slow proliferation, such as liver cells [ 45 ] . While β-cells were not examined in that study, they certainly exhibit both high oxidative metabolism and a low rate of proliferation, consistent with them being a target for the effects of 8-OH-dG adducts.