Example sentences for: oh-dg

How can you use “oh-dg” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Unfortunately, we were unable to obtain specific staining with antibodies to 8-OH-dG.

  • In light of the previous publication on the role of 8-OH-dG adducts in a rat model of type 2 diabetes [ 31 ] , and the finding that the Ogg1 gene was over-expressed in human type 2 diabetes, we evaluated the expression of Ogg1 protein in pancreas specimens from type 2 diabetic and healthy subjects, as a marker for β-cell oxidative DNA damage in type 2 diabetes.

  • The reason for this is that we found high levels of background staining with the anti-8-OH-dG antibodies, which is not unusual when using streptavidin/biotin detection systems in immunohistochemistry [ 39 ] . Unfortunately, secondary antibodies directly linked to a fluorophore or a detection enzyme were not sensitive enough to detect the 8-OH-dG adduct in our hands.

  • Increases in Ogg1 activity and expression have been found by a number of investigators [ 35 36 37 ] . Although antibodies to 8-OH-dG exist [ 38 ] , Ogg1 was used as a surrogate for the amount of oxidative DNA damage.

  • This enzyme is the major repair enzyme involved in the defense against accumulation of the 8-OH-dG adducts discussed above.


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