Words similar to oh-dg

Example sentences for: oh-dg

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The reason for this is that we found high levels of background staining with the anti-8-OH-dG antibodies, which is not unusual when using streptavidin/biotin detection systems in immunohistochemistry [ 39 ] . Unfortunately, secondary antibodies directly linked to a fluorophore or a detection enzyme were not sensitive enough to detect the 8-OH-dG adduct in our hands.
Unfortunately, we were unable to obtain specific staining with antibodies to 8-OH-dG.
Ogg1 knockout mice possess increased levels of 8-OH-dG in their genome, particularly in the mitochondrial genome, but do not seem to exhibit an increased frequency of malignancies [ 44 45 46 ] . It was postulated that the consequences of 8-OH-dG adducts and Ogg1 deficiency affects mainly cells with high oxygen metabolism and slow proliferation, such as liver cells [ 45 ] . While β-cells were not examined in that study, they certainly exhibit both high oxidative metabolism and a low rate of proliferation, consistent with them being a target for the effects of 8-OH-dG adducts.
Such an apoptotic defect could account for the increasing intensity of Ogg1 staining, following accumulated levels of 8-OH-dG adducts with longer duration of diabetes.
In a study published after this report was submitted, an increased number of 8-OH-dG positive islet cells in human type 2 diabetic subjects was observed [ 32 ] . The staining was found to be mainly nuclear in contrast to the cytoplasmic Ogg1 staining found in the present report.