Words similar to oh-dg

Example sentences for: oh-dg

How can you use “oh-dg” in a sentence? Here are some example sentences to help you improve your vocabulary:

Unfortunately, we were unable to obtain specific staining with antibodies to 8-OH-dG.
However, the nuclear localization of 8-OH-dG [ 32 ] and the increased Ogg1 reported here are consistent with a model in which mitochondrial Ogg1 is up-regulated but nuclear Ogg1 is not, leading to an increase in nuclear but not mitochondrial 8-OH-dG adducts [ 32 ] . Further studies will be required to resolve this issue, but β-cells in type 2 diabetes may well suffer from both nuclear and mitochondrial DNA damage, leading to decreased β-cell function and eventual loss of β-cell mass.
The reason for this is that we found high levels of background staining with the anti-8-OH-dG antibodies, which is not unusual when using streptavidin/biotin detection systems in immunohistochemistry [ 39 ] . Unfortunately, secondary antibodies directly linked to a fluorophore or a detection enzyme were not sensitive enough to detect the 8-OH-dG adduct in our hands.
Increases in Ogg1 activity and expression have been found by a number of investigators [ 35 36 37 ] . Although antibodies to 8-OH-dG exist [ 38 ] , Ogg1 was used as a surrogate for the amount of oxidative DNA damage.
We interpret the upregulation of Ogg1 as a response to an increased level of 8-OH-dG DNA, the lesion that it repairs.