Words similar to nucleotidyl
Example sentences for: nucleotidyl
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The classical adenylyl cyclases, guanylyl cyclases and the GGDEF (diguanylate cyclase) domains share the catalytic palm domain with the family B DNA polymerases, reverse transcriptases, viral RNA dependent RNA polymerases and eukaryote-type primases [ 4 13 14 ] . The pathogenic adenylyl cyclases of several bacteria and the CyaA-like proteobacteria adenylyl cyclases are extremely divergent versions of the catalytic domain seen in the Pol-β family of nucleotidyl transferases [ 15 ] (also see SCOP database: http://scop.mrc-lmb.cam.ac.uk/scop/).
HD domains typically possess phosphoesterase activity, and are fused to catalytic domains that possess nucleotide kinase, nucleotidyltransferase, nucleotide cyclase or diguanylate cyclase activity [ 19 29 ] . This fits well with the observed cyclase activity seen in CyaB, but is also consistent with phosphotransferase or nucleotidyl transferase for the CYTH domain.
In contrast to the template-dependent RNA polymerases, which have several distinct scaffolds of the catalytic domains, all template-independent RNA polymerases have the same fold of the principal catalytic domain and belong to the pol β superfamily of nucleotidyl transferases [ 29 30 ] .
Analogous active sites, that coordinate two metal ions, are observed in domains with similar activities, such as the classical adenylyl/guanylyl cyclases, family B DNA polymerases, pol-β fold nucleotidyl transferases, and triphosphatases or phosphoesterases of the HD and DHH superfamilies [ 11 15 19 20 ] . Consistent with these observations, both CyaB and ThTPase have been shown to require Mg 2+ions for their nucleotide cyclase and phosphatase activities [ 16 17 ] .
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