Words similar to nsgcts
Example sentences for: nsgcts
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3%) NSGCTs (Fig.
Four of the five SGCTs that exhibited promoter hypermethylation were methylated at a single locus and one tumor at two loci, whereas 27 of the 38 NSGCTs exhibited two or more methylated loci.
Several studies have shown that both NSGCTs and SGCTs exhibit similar genetic alterations, including isochromosome for the short arm of chromosome 12, i(12p) [ 6 ] . Thus epigenetic alterations such as those detected in the current study is one distinct molecular change that distinguishes these two histologic subsets.
To examine the biological role of promoter hypermethylation in GCT, we assessed the levels of gene expression by semi-quantitative RT-PCR in 23 tumors (15 NSGCTs and 8 SGCTs) with known methylation status.
Histologically, 29 of these tumors were SGCTs, 44 NSGCTs, and 19 mixed or combined tumors.