Words similar to nsgcts
Example sentences for: nsgcts
How can you use “nsgcts” in a sentence? Here are some example sentences to help you improve your vocabulary:
Four of the five SGCTs that exhibited promoter hypermethylation were methylated at a single locus and one tumor at two loci, whereas 27 of the 38 NSGCTs exhibited two or more methylated loci.
The overall higher frequency of promoter methylation seen in NSGCTs is noticeably evident in DNA repair genes RASSF1A, BRCA1 , and MGMT , and the hypermethylated in cancer 1 ( HIC1 ) gene, which encodes a transcription factor.
3%) NSGCTs (Fig.
Histologically, 29 of these tumors were SGCTs, 44 NSGCTs, and 19 mixed or combined tumors.
A unique feature of GCTs is their origin from germ cells at a stage in development where they undergo epigenetic reprogramming [ 6 13 ] . The absence of this epigenetic modification in SGCTs is consistent with their GC-like nature as previously noted [ 6 14 ] . On the other hand, the extensive promoter hypermethylation seen in NSGCTs suggests a mechanistic role in their potential for embryonal and extra-embryonal lineage differentiation [ 6 14 ] . Establishment of DNA methylation in the mammalian genome is controlled by at least three DNA methyltransferases (DNMTs), DNMT1 , DNMT3a and DNMT3b [ 15 ] . The role of these DNMTs in differential de novo methylation in SGCT vs.
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