Words similar to nsclc

Example sentences for: nsclc

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In an effort to explain the selective advantage of cells with a newly identified “resistance” mutation in EGFR— a T790M amino acid substitution—we further characterized the drug sensitivity of putatively resistant EGFR mutants versus wild-type or drug-sensitive EGFR mutants, using both a NSCLC cell line fortuitously found to contain the T790M mutation and lysates from cells transiently transfected with wild-type and mutant EGFR cDNAs.
Significant differences were seen when comparing measurements from 38 NSCLC samples to 9 normals (234+/-40 vs.519+/-54; p = 0.0167) and 27 NSCLC patient samples to 16 normals (846+/-62 vs. 1838 +/-213; p = 0.0011) (Figure 2).
Data show adherent mononuclear cells from NSCLC patients produced baseline levels of IL10 significantly greater than those of normal volunteers (40 ± 25 vs. 574 ± 127; p < 0.01; Figure 3).
Several mutations have been identified in the context of epidermal growth factor receptor (EGFR) in patients with NSCLC that are associated with clinical response to the small-molecule EGFR inhibitors gefitinib (Iressa) or erlotinib (Tarceva) [7,8,9], including in-frame deletions such as del L747–E749;A750P in exon 19, or L858R in exon 21.
More recently, this paradigm has been extended to treatment of non-small cell lung cancer (NSCLC).