Example sentences for: nrs

How can you use “nrs” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We do not understand why, but in our hands, transfected N-CoR also fails to affect TR or ERα activity (data not shown), despite the fact that it clearly interacts with both NRs.

  • NRs generally interact with the corepressors N-CoR and SMRT either in the absence of ligand, or in the presence of receptor antagonists, and agonists promote corepressor release [ 4 ] . In this study, we demonstrated that ERβ binds to N-CoR in the presence of ER agonists such as estradiol and DES and the phytoestrogens genistein and coumestrol, but not in the presence of SERMs.

  • Unliganded NRs usually bind ID motifs (consensus L/IXXIIXXXL) in the N-CoR C-terminus.

  • NRs consist of three domains, the N-terminal domain (which contains a context-specific activation function AF-1), the central DNA binding domain (DBD) and the C-terminal ligand binding domain (LBD), which contains a hormone-dependent activation function, AF-2.

  • JDB has proprietary interests in, and serves as consultant and deputy director to Karo Bio AB, a Swedish company that develops pharmaceuticals that target NRs.


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