Example sentences for: nrs

How can you use “nrs” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • NRs generally interact with the corepressors N-CoR and SMRT either in the absence of ligand, or in the presence of receptor antagonists, and agonists promote corepressor release [ 4 ] . In this study, we demonstrated that ERβ binds to N-CoR in the presence of ER agonists such as estradiol and DES and the phytoestrogens genistein and coumestrol, but not in the presence of SERMs.

  • Next, we examined whether the β-box would bind other NRs.

  • JDB has proprietary interests in, and serves as consultant and deputy director to Karo Bio AB, a Swedish company that develops pharmaceuticals that target NRs.

  • The nuclear receptor (NR) family comprises 48 structurally related transcription factors, many of which require their cognate ligand for activity [ 1 2 3 ] . The NRs regulate transcription by binding to response elements in the promoters of target genes and acting as scaffolds for the assembly of large coactivator and corepressor complexes [ 4 ] . NR coactivators include the p160s (including GRIP1/TIF-2, SRC-1 and AIB1/ACTR/pCIP).

  • Unliganded NRs usually bind ID motifs (consensus L/IXXIIXXXL) in the N-CoR C-terminus.


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