Words similar to nrbexpression
Example sentences for: nrbexpression
How can you use “nrbexpression” in a sentence? Here are some example sentences to help you improve your vocabulary:
We have previously shown that nmt55/p54 nrbprotein was expressed in most ER+/PR+ human breast tumors but was undetectable in ER-/PR- human breast tumors [ 13 ] . Since loss of hERα expression is associated with poor prognosis and continued expression of hERα is associated with disease-free survival and correlates well with tumor differentiation state, we wanted to investigate the regulation of nmt55/p54 nrbexpression.
Results from Western blot analyses with polyclonal antibodies NMT-4 and NMT-5 showed that nmt55/p54 nrbexpression was absent, or greatly reduced, in most of ER- tumors.
We have previously investigated nmt55/p54 nrbprotein expression in human breast tumors and observed a statistically significant association between decreased nmt55/p54 nrbexpression, loss of hERα and hPR and increased tumor size [ 13 ] . It is possible that decreased nmt55/p54 nrbexpression represents poor tumor differentiation, increased tumor growth and metastases since reduced or absent hERα expression and function correlates with poor tumor differentiation [ 11 36 ] and tumor size is a strong indicator of tumor progression [ 37 ] . Here we investigated nmt55/p54 nrbmRNA expression using Northern blot analyses and ribonuclease protection assays to determine if the reduction of nmt55/p54 nrbprotein expression was the result of transcriptional regulation.
Our data suggests that nmt55/p54 nrbmay be critical to cell growth and function, such that, decreased nmt55/p54 nrbexpression in ER- human breast tumors or the expression of nmt55/p54 nrbvariants in ER+ tumors may indicate loss of normal growth, nmt55/p54 nrbhas been shown in several studies to bind RNA and interact with PSF and Topoisomerase I [ 14 16 17 18 19 20 39 ] . Those results along with our observations that nmt55/p54 nrbassociates with several splicing factors essential for spliceosome formation (unpublished) and relates to tumor hormonal status [ 13 ] suggest that nmt55/p54 nrbmay be involved in pre-mRNA processing.
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