Words similar to novobiocin

Example sentences for: novobiocin

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While novobiocin acts primarily as a DNA gyrase inhibitor, resistance is mediated by the concentration of phospholipids in the outer membrane, for which the cls gene (encoding cardiolipin synthase) is partly responsible [ 33 ] . Again, if selection had increased membrane permeability, sensitivity to novobiocin might have increased relative to the partially resistant ancestor.
Only one absolute catabolic loss (D-ribose) [ 36 ] was observed in all twelve lineages, and one additional function (resistance to novobiocin) was lost in most populations.
Novobiocin resistance is an ancestral character that is sometimes dependent upon mutations in the cell envelope, including the structural component lipopolysaccarides as well as outer membrane porins [ 32 ] . Assays were conducted by distributing approximately 250 cells on LB plates containing 400 μg/ml novobiocin.
Most populations become sensitive to novobiocin
Assays that examined the ability of each population to grow on agar plates containing novobiocin demonstrated that most populations became sensitive to this antibiotic (not shown).