Words similar to novobiocin

Example sentences for: novobiocin

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Assays that examined the ability of each population to grow on agar plates containing novobiocin demonstrated that most populations became sensitive to this antibiotic (not shown).
Bile salts are like novobiocin in that both are antibiotics that interact with the outer membrane, but their mechanisms of interaction and their effects on these populations are rather different.
Most populations completely lost the ability to grow in the presence of novobiocin, which suggests an increase in membrane permeability [ 33 ] . However, no significant differences in fitness were found when bile salts were added to the selective medium, indicating that the mechanisms of increased outer membrane permeability were not detrimental to bile resistance.
While novobiocin acts primarily as a DNA gyrase inhibitor, resistance is mediated by the concentration of phospholipids in the outer membrane, for which the cls gene (encoding cardiolipin synthase) is partly responsible [ 33 ] . Again, if selection had increased membrane permeability, sensitivity to novobiocin might have increased relative to the partially resistant ancestor.
The contrary findings of novobiocin sensitivity and bile salt resistance have already been presented, but these results, along with other catabolic phenotypes, potentially limit the gene candidates upon which selection may have acted to improve life in a simple glucose-limited environment.