Words similar to novobiocin

Example sentences for: novobiocin

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Only one absolute catabolic loss (D-ribose) [ 36 ] was observed in all twelve lineages, and one additional function (resistance to novobiocin) was lost in most populations.
Most populations completely lost the ability to grow in the presence of novobiocin, which suggests an increase in membrane permeability [ 33 ] . However, no significant differences in fitness were found when bile salts were added to the selective medium, indicating that the mechanisms of increased outer membrane permeability were not detrimental to bile resistance.
This may reflect an ability of E. coli to actively export bile salts that was unaffected by this experiment [ 31 ] . Thus, if changes in membrane permeability (perhaps through modified expression of genes like cls [ 33 ] ) were responsible for the loss of novobiocin resistance, they apparently had specific effects that did not compromise other membrane traits like tolerance to bile salts.
Novobiocin resistance is an ancestral character that is sometimes dependent upon mutations in the cell envelope, including the structural component lipopolysaccarides as well as outer membrane porins [ 32 ] . Assays were conducted by distributing approximately 250 cells on LB plates containing 400 μg/ml novobiocin.
Assays that examined the ability of each population to grow on agar plates containing novobiocin demonstrated that most populations became sensitive to this antibiotic (not shown).