Words similar to non-muscle
Example sentences for: non-muscle
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Voltage-gated K +channels in non-nerve, non-muscle cells play crucial roles in cell development, proliferation, migration, volume regulation, as well as maintenance of membrane potential and cell viability.
Hormonal signal transduction and steroidogenesis can be affected by changes in intracellular and extracellular concentrations of inorganic ions, cellular resting membrane potential, and cell size [ 29 30 35 54 55 56 57 58 59 ] . Blockade of 4-AP sensitive K +channels in non-nerve, non-muscle cells can lead to changes in transmembrane ion gradients, membrane potential and cell volume [ 42 60 ] . On this basis, we determined the effects of 24 h exposure to 4-AP on GC size, membrane potential and intracellular potassium ([K +] in ).
An important aspect of actin cytoskeletal research has been the use of small molecules that affect actin dynamics and proteins that act on the cytoskeleton [ 1 ] . 2,3-butanedione monoxime (BDM) is a small molecule that inhibits the ATPase activity of muscle myosinII and reduces the force generated by this motor protein [ 2 3 ] . BDM was introduced to the cell biology community as a millimolar inhibitor of multiple non-muscle myosins with greatest potency in inhibiting non-muscle myosinII [ 4 ] . It was subsequently used, in concert with other approaches, to study nm-myosinII function in a variety of biological processes [ 5 6 7 8 ] . BDM was recently shown not to inhibit any non-muscle myosins so far tested, leaving the question of how it affects cells unanswered [ 9 10 ] .
Data obtained previously in our laboratory suggest that inhibition of granulosa I Kur should be associated with a +10 to +20 mV depolarization of cell resting membrane potential; block of I Ks alone decreased resting potential by +10 mV while block of both I Ks and I Kur decreased resting potential by +20 to +30 mV [ 18 ] . Most previous investigations of 4-AP effects on the resting membrane potentials of non-nerve, non-muscle cells have similarly demonstrated drug-induced depolarization [ 42 60 ] , although there is a single report showing 4-AP-induced hyperpolarization of chondrocyte membrane potential [ 62 ] .
In addition, a construct that is driven by the exon 1c promoter is expressed in various types of muscle cells [ 27 ] . However, it is also expressed in a number of non-muscle cells.
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