Words similar to nm-myosin
Example sentences for: nm-myosin
How can you use “nm-myosin” in a sentence? Here are some example sentences to help you improve your vocabulary:
One new compound that will help clarify the role of nm-myosinII is blebbistatin [ 32 ] . Other small molecules wait to be found and experiments using them will continuously refine our understanding of the leading edge and the mechanism of action of these compounds.
BDM has recently been found not to inhibit the in vitro ATPase activity of human platelet nm-myosinII, Acanthamoeba myosinIc, human myoIe, chicken myosinV, and porcine myosinVI, though it does inhibit rabbit muscle myosinII [ 9 10 ] . Thus the literature's interpretations of BDM's effects are probably incorrect.
Inhibition of retrograde flow by BDM has been used as evidence for the role of nm-myosins in retrograde flow [ 12 ] . Though not explicitly stated, the localization and importance of nm-myosinII in multiple cell types, and the fact that BDM was thought to have greatest potency in inhibiting nm-myosinII has led most to look at BDM's effect on retrograde flow as a result of inhibiting this protein.
Though BDM does not inhibit nm-myosinII, in permeabilized yeast ( S. cerviseae ) BDM has been shown to decrease incorporation of exogenous actin into the cytoskeleton [ 20 ] . This process of actin incorporation requires proteins involved in actin filament formation and proteins that may localize a nucleation complex [ 20 21 ] . To determine if BDM has a similar effect on actin incorporation in mammalian cells, and if so an effect on actin nucleation, spreading Swiss3T3 cells were treated briefly with a media control or 15 mM BDM and then permeabilized with the detergent saponin in the presence of fluorescently labeled actin.
BDM has been reported to not inhibit nm-myosinII ATPase activity [ 9 ] . We show data [Figure 1A] that supports this report.
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