Words similar to nm-myosin
Example sentences for: nm-myosin
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Inhibition of retrograde flow by BDM has been used as evidence for the role of nm-myosins in retrograde flow [ 12 ] . Though not explicitly stated, the localization and importance of nm-myosinII in multiple cell types, and the fact that BDM was thought to have greatest potency in inhibiting nm-myosinII has led most to look at BDM's effect on retrograde flow as a result of inhibiting this protein.
BDM has been reported to not inhibit nm-myosinII ATPase activity [ 9 ] . We show data [Figure 1A] that supports this report.
One new compound that will help clarify the role of nm-myosinII is blebbistatin [ 32 ] . Other small molecules wait to be found and experiments using them will continuously refine our understanding of the leading edge and the mechanism of action of these compounds.
The ATPase activity of platelet nm-myosinII S1 fragment, is not inhibited by BDM while the inhibitor, blebbistatin, decreases ATPase activity by more than 90%.
[ 11 17 18 ] . A role for nm-myosinII may exist, given its localization and that other perturbations that affect myosin function - myosin S1 microinjection, ML-7 treatment, and expression of dominant negative nm-myosinII constructs and have similar effects to BDM treatment [ 5 7 12 ] . However, a study in chick dorsal root ganglia neurons where nm-myosinII was inactivated using chromophore assisted laser inactivation saw no effect on retrograde flow rates [ 19 ] . We know now that BDM does not in fact inhibit nm-myosinII.