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Example sentences for: nidulans
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Rad26 is a regulatory subunit of the Rad26/Rad3 complex that is required for Rad3 kinase activity [ 18 ] . Following DNA damage, Rad26 undergoes Rad3-dependent phosphorylation [ 17 ] . Rad26 is a 70 kDa protein containing little informative sequence information beyond a predicted coiled-coil region and a basic stretch that resembles a nuclear localization signal [ 13 32 ] . Functionally conserved proteins with very weak sequence similarity have been found in human (ATRIP) [ 35 ] , S. cerevisiae LCD1 (aka DDC2 and PIE1) [ 36 37 38 ] and A. nidulans (UVSD) [ 32 ] .
Other PIKK family members also function to orchestrate eukaryotic genotoxic stress responses, including human ATM, ATR, and DNA-dependent protein kinase (DNA-PKcs), TEL1 and MEC1 of Saccharomyces cerevisiae , Mei-41 of Drosophila and UVSB of Aspergillus nidulans [ 5 32 33 34 ] .
Two moeB sequences with evidence for function include a knockout of the open reading frame encoding GenBank accession number BAA35521, which was shown to cause the accumulation of precursor Z in E. coli [ 13 ] and accession number Z95150, which was found to be located within a cluster of other MPT-Mo synthesis genes of Mycobacterium tuberculosis [ 14 ] . MSAEs from eukaryotic organisms have also been characterized: MOCS3 (GenBank accession number NM_014484) from humans and cnx 5 from Arabidopsis thaliana [ 15 ] , respectively, have been sequenced, and cnxF from Aspergillus nidulans [ 16 ] has been both sequenced and physiologically characterized.
MoeB, exemplified by Ec-MoeB, and MoeBR, exemplified by cnxF of Aspergillis nidulans [ 16 ] , participate in the synthesis of MPT-Mo as MSAEs.
Examples of both MoeB ( E. coli ) and MoeBR (CNXF of A. nidulans ) have been characterized as MSAEs, indicating that the C-terminal rhodanese-like domain addition does not inhibit MSAE activity.
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