Words similar to nicotinic
Example sentences for: nicotinic
How can you use “nicotinic” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, the concentration of α-ARD immunoreactivity in the region of the VS cell dendrites at the posterior border of the lobula plate is in accordance with our earlier findings of nicotinic receptor responses in these neurons [ 23].
Tetraethylammonium is known as a pore-occluding blocker of voltage-gated potassium channels [ 1 ] , but it also blocks other cationic channels such as calcium-dependent K +channels [ 2 3 ] and the nicotinic acetylcholine receptor [ 4 ] . TEA at 0.1 to 10 mM also inhibits osmotic water flux through human AQP1 channels expressed in Xenopus oocytes, decreasing the net swelling rate in hypotonic saline by 30-40% as compared to AQP1-expressing oocytes not treated with TEA [ 5 ] . This blocking effect on osmotic water flux was demonstrated to involve AQP1 channels specifically by using site-directed mutagenesis (tyrosine 186 to phenylalanine) to generate a Y186F AQP1 channel that is insensitive to block by TEA, but retains sensitivity to block by mercury.
Our staining pattern for nicotinic acetylcholine receptors as demonstrated with the α-ARD antibody resembles very closely the pattern observed originally in
On a gross level, all members of this superfamily assemble as pentameric receptors [ 4 ] . In some cases, receptors can be assembled from a single subunit (5-HT 3A R and nicotinic α7 receptors) [ 1 5 6 7 8 ] . In other cases, at least two different subunits are required [ 2 4 9 ] . The ligand binding site is thought to be formed at the junction between two subunits [ 2 4 ] .
Based on data obtained from affinity labeling and site directed mutagenesis studies, several regions of the nicotinic acetylcholine receptor have been implicated in ligand binding [ 10 ] . Six essential loops appear to contribute to the binding site with the position of each loop differing slightly depending on whether the receptor is heteromeric or homomeric [ 4 ] . For homomeric receptors such as the α7 nAChR, the loops are identified as A, B, C, D, E and F [ 4 11 ] . The amino acids that interact with ligands presumably extend into the binding site from these loops.
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