Words similar to nicotinic
Example sentences for: nicotinic
How can you use “nicotinic” in a sentence? Here are some example sentences to help you improve your vocabulary:
A previous report using immunofluorescence demonstrated colocalization of RIα with the nicotinic acetylcholine receptor (nAChR) at the NMJ postsynaptic membrane [ 19 ] . We used immunohistochemistry coupled with confocal microscopy to acquire detailed information as to the intracellular localization of D-AKAP1 in the several regions of the NMJ and adjacent intercostal muscle to compare with that of RIα.
Before the availability of antibodies against nicotinic acetylcholine receptors of dipteran flies, cholinergic pathways have been analyzed by more indirect methods, mainly by immunocytochemistry against choline acetyltransferase (ChAT), an enzyme of the acetylcholine metabolism [ 38, 39] or autoradiography of 125I-α-bungarotoxin binding [ 40, 41].
So I'm cautiously optimistic that we're on the road to developing some useful nicotinic therapies.”
Based on data obtained from affinity labeling and site directed mutagenesis studies, several regions of the nicotinic acetylcholine receptor have been implicated in ligand binding [ 10 ] . Six essential loops appear to contribute to the binding site with the position of each loop differing slightly depending on whether the receptor is heteromeric or homomeric [ 4 ] . For homomeric receptors such as the α7 nAChR, the loops are identified as A, B, C, D, E and F [ 4 11 ] . The amino acids that interact with ligands presumably extend into the binding site from these loops.
Dani points out that the body's own agent, acetylcholine, acts over milliseconds to activate nicotinic receptors, whereas nicotine itself stimulates these receptors for hours.
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