Words similar to neutralizing
Example sentences for: neutralizing
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Polyclonal goat anti-murine MIG/CXCL9 and anti-murine IP-10/CXCL10 specific anti-serum were produced and characterized as previously described [ 31 ] . Anti-mouse IFNγ monoclonal (R4-462, American Type Culture Collection, Rockville, Maryland, MD) neutralizing antibody was purified by affinity chromatography from SCID mice ascites, which was generated 3-4 weeks after intraperitoneal injection of 10 6R4-462 hybridoma cells per mouse [ 32 ] . For flow cytometry, labeled antibodies (FITC, PE, PerCP) against the T cell surface markers to CD3, CD4, CD8 and against the DC markers, CD11c and DEC 205 and the appropriate controls were purchased from PharMingen.
Neutralizing antibodies induced by CMV are directed primarily against the major envelope protein of CMV, glycoprotein B (gB).
Neutralizing antihuman IFN-γ antibody was from Endogen (Cambridge, MA, USA).
Treatment with recombinant IL-10 in CIA, in proteoglycan-induced arthritis, and in experimental autoimmune encephalomyelitis reduced disease severity, and neutralizing IL-10 with antibodies exacerbated disease [ 19 20 22 23 ] . The present data are consistent with previous results and show that a complete absence of IL-10 exacerbates inflammation in CIA [ 37 38 39 ] . The anti-inflammatory properties of IL-10 suggest that endogenous IL-10 may function as a regulator of proinflammatory mediators in vivo [ 39 ] . It is interesting, however, that disease severity inversely correlates with the levels of IFN-γ in IL-10 -/-mice, suggesting that IL-10 may control disease activity via regulating IFN-γ responses.
Girasole et al have recently shown that production of IL-6 is inhibited in vitro by exposure of marrow cells to 17β-estradiol; cultures of mouse bone cells showed suppressed osteoclast development when exposed to either 17β-estradiol or a neutralizing antibody to Il-6 [ 31].
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