Words similar to neurokinin
Example sentences for: neurokinin
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In addition to the binding sites for natural or endogenous agonists (orthosteric sites), many GPCRs have also been found to have allosteric sites [ 35 ] . These sites can bind natural ligands, as in the case of Zn ions and heparin for the dopamine and neurokinin receptors, respectively, or bind synthetic drugs such gallamine, in the case of the muscarinic receptors [ 35 ] . Binding of small molecules to these allosteric sites can modulate activity of a receptor without directly mimicking or competing out the interaction of ligands to the orthosteric sites.
3. The widespread distribution of neurokinin-immunoreactive fibers and cell bodies indicates that neurokinin might be involved in several physiological functions, acting as a neurotransmitter and/or neuromodulator.
Moreover, control sections were incubated in the primary antiserum previously absorbed by neurokinin A or neurokinin B. Inhibition of staining was obtained after preincubation of the first antiserum with neurokinin A (10 -4and 10 -5M) or with neurokinin B (10 -3M).
Thus, in the present work we attempted to study in detail the distribution of fibers and cell bodies containing neurokinin in the human brainstem, using an immunoperoxidase technique, and to compare our findings with the distribution of other tachykinins previously described in the human brainstem [ 23 24 25 27 ] . Finally, we report here a widespread distribution of fibers and cell bodies containing neurokinin in the human brainstem.
It is also known that the biological actions of NKA, NKB and SP are mediated by three receptors, named neurokinin (NK)-1, NK-2 and NK-3 [ 2 ] . Thus, the tachykinins have been implicated in several physiological actions such as salivation, the regulation of smooth muscle contraction, depolarization of central neurons, hyperactivity, interaction with dopaminergic A-10 neurons mediating behavioral activation, regulation of blood pressure, and the transmission of the baroreceptor reflex [ 3 4 5 6 7 ] . In addition, a loss of tachykinin-containing neurons has been described in neurodegenerative diseases [ 8 ] , suggesting that the decrease in the amount of tachykinins could be involved in these and other diseases [ 9 10 ] .
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