Words similar to neurokinin
Example sentences for: neurokinin
How can you use “neurokinin” in a sentence? Here are some example sentences to help you improve your vocabulary:
The specificity of the immunostaining was controlled by omission of the neurokinin antibody in the first incubation bath.
Several inmunocytochemical, " in situ " hybridization and radioimmunoassay studies have demonstrated the distribution of tachykinins in the rat, the cat and the monkey CNS [ 11 12 13 14 15 16 17 18 19 20 ] . In the human brainstem, the presence of SP has been widely studied [ 21 22 23 24 25 26 27 ] . Moreover, in humans, the neurokinin B system has been studied in the cerebral cortex, hippocampus and the hypothalamus [ 28 ] . However, no data are available in the literature concerning the distribution of neurokinin-immunoreactive structures in the human brainstem.
3. The widespread distribution of neurokinin-immunoreactive fibers and cell bodies indicates that neurokinin might be involved in several physiological functions, acting as a neurotransmitter and/or neuromodulator.
In addition to the binding sites for natural or endogenous agonists (orthosteric sites), many GPCRs have also been found to have allosteric sites [ 35 ] . These sites can bind natural ligands, as in the case of Zn ions and heparin for the dopamine and neurokinin receptors, respectively, or bind synthetic drugs such gallamine, in the case of the muscarinic receptors [ 35 ] . Binding of small molecules to these allosteric sites can modulate activity of a receptor without directly mimicking or competing out the interaction of ligands to the orthosteric sites.
The mammalian tachykinin peptides include neurokinin A (NKA), neurokinin B (NKB) and substance P (SP) [ 1 ] . It is known that these three neuropeptides have a common C-terminal amino acid sequence and that NKA and SP are derived from the preprotachykinin A gene, whereas NKB is derived from the preprotachykinin B gene.
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