Words similar to neurogranin
Example sentences for: neurogranin
How can you use “neurogranin” in a sentence? Here are some example sentences to help you improve your vocabulary:
Neurogranin has been shown to be phosphorylated by PKCγ, and this phosphorylation is greatly decreased in PKCγ knockout mice, suggesting neurogranin is a PKCγ-specific substrate [ 9 ] . Evidence that strongly suggests the phosphorylation of neurogranin plays an important role in neural plasticity comes from the studies that demonstrated neurogranin knockout mice show essentially the same deficits in behaviors related to learning and memory as that of the PKCγ knockout mice [ 10 ] . Neurogranin is not only a substrate of PKCγ, but also plays a important role in regulating PKC signaling [ 11 ] . Interstingly, PKCγ knockout mice demonstrate reduced neuropathic pain [ 12 ] . Similar to neurogranin, we found that a calmodulin-binding, vesicle-associated, CAM kinase IV-like protein is highly expressed and enriched in the superficial layer of the dorsal spinal cord.
We found that the dorsally enriched genes also include several members of the calcium sensor protein family, such as vesicle associated calcium calmodulin binding protein (CAMK IV homolog), PKCγ substrate neurogranin, chromogranin, neurovisinin-like protein, secretogranin, and hippocalcin.
The colocalization of neurogranin and PKCγ in similar regions in the spinal cord suggests that neurogranin may be an endogenous substrate of PKCγ in the spinal cord.
3. In situ hybridization and immunohistochemistry revealed that neurogranin, CAMK IV homolog, Galpha(olf), and Syntaxin 1A, are indeed enriched in the dorsal spinal cord.
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