Words similar to nestin
Example sentences for: nestin
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Recent experiments by Fults and colleagues support the idea that stabilized β-catenin expression in the postnatal CNS is not sufficient to initiate tumor formation [ 36 ] . Using the RCAS-TVA system they showed that overexpression of c-myc, but not of activated β-catenin, promoted the proliferation of neural progenitor cells in vivo and in vitro . In their in vivo experiments expression was initiated in nestin positive cells postnatally via injection of β-catenin stabilized by a point mutation in codon 37.
For quantification of cells expressing Nestin, Ki67, β-tubulin III, activated caspase-3, insulin, or C-peptide, NS-derived cell clusters were fixed, and sectioned to generate 7-μm-thick tissue sections.
Chenn and Walsh recently created transgenic mice in which β-catenin stabilized by an amino-terminal truncation was expressed in subventricular zone precursor cells in utero under control of the nestin promoter [ 22 ] . Brains from these transgenic embryos contained increased numbers of periventricular neuroepithelial cells because a greater number of the precursors re-entered the cell cycle after mitosis.
Insulin + cells showed little or no co-expression of neural stem cell markers like Nestin (see Figure 1), or other markers of neural lineages known to develop from human neural progenitors, like MAP2 (differentiated neurons; Figure 5D–5F), Olig2 (multipotent precursors, bipotent glial precursors, and oligodendrocytes; Figure 5J–5L; see [38]), or myelin basic protein (data not shown).
In stage 3 cultures, Nestin and Ki67 expression was nearly extinguished (see Figure 2), while expression of En1, ngn3, and Hb9 increased (see Figure 1B and 1C).
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