Words similar to nephrosclerosis
Example sentences for: nephrosclerosis
How can you use “nephrosclerosis” in a sentence? Here are some example sentences to help you improve your vocabulary:
The inbred Dahl/Rapp rat is a genetic model of salt-sensitive hypertension [ 3 4 ] . On a diet containing 8.0% NaCl, young Dahl/Rapp salt-sensitive (S) rats rapidly and uniformly manifest low-renin hypertension and die from hypertensive nephrosclerosis within weeks of institution of the high-salt diet [ 5 ] . The pathology is identical to human hypertensive renal disease and consists of arteriolosclerosis, glomerulosclerosis, and interstitial scarring with tubular cell dropout.
Apoptosis can be significant particularly three weeks into the course of hypertensive nephrosclerosis in this model (Figure 1).
These data, along with the previous studies that confirmed morphological evidence of apoptosis and biochemical evidence of caspase-3 activation in these kidneys [ 7 ] , showed a role for the Fas/FasL pathway in promoting the loss of kidney function that develops in the setting of hypertensive nephrosclerosis in this model.
Recent studies have shown that apoptosis was accentuated in kidneys of S rats during development of nephrosclerosis [ 7 ] . These studies demonstrated increased numbers of TUNEL-positive cells, increased cytoplasmic nucleosome content and caspase-3 activation in kidneys of hypertensive S rats, compared to normotensive Sprague-Dawley control rats on the same high-salt diet.
In kidneys of S rats, associated with apoptosis was a temporal increase in expression of Fas, which was demonstrated using Western analysis of lysates of kidney cortex [ 7 ] . The purpose of the present study was to demonstrate the site of expression and potential functional significance of Fas and FasL in the kidneys of S rats during development of hypertensive nephrosclerosis.
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