Example sentences for: nephrosclerosis

How can you use “nephrosclerosis” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Recent studies have shown that apoptosis was accentuated in kidneys of S rats during development of nephrosclerosis [ 7 ] . These studies demonstrated increased numbers of TUNEL-positive cells, increased cytoplasmic nucleosome content and caspase-3 activation in kidneys of hypertensive S rats, compared to normotensive Sprague-Dawley control rats on the same high-salt diet.

  • The pronounced increases in Fas and FasL expression and activation of this pathway by the third week of study also correlated with previous evidence that documented irreversibility of the renal injury if the hypertension was not corrected by this time [ 5 ] . These data supported the view that the Fas/FasL pathway promoted nephrosclerosis in this model.

  • Apoptosis can be significant particularly three weeks into the course of hypertensive nephrosclerosis in this model (Figure 1).

  • In kidneys of S rats, associated with apoptosis was a temporal increase in expression of Fas, which was demonstrated using Western analysis of lysates of kidney cortex [ 7 ] . The purpose of the present study was to demonstrate the site of expression and potential functional significance of Fas and FasL in the kidneys of S rats during development of hypertensive nephrosclerosis.

  • The role of the Fas/FasL pathway in human hypertensive nephrosclerosis remains to be determined.


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