Words similar to nephrosclerosis
Example sentences for: nephrosclerosis
How can you use “nephrosclerosis” in a sentence? Here are some example sentences to help you improve your vocabulary:
The inbred Dahl/Rapp rat is a genetic model of salt-sensitive hypertension [ 3 4 ] . On a diet containing 8.0% NaCl, young Dahl/Rapp salt-sensitive (S) rats rapidly and uniformly manifest low-renin hypertension and die from hypertensive nephrosclerosis within weeks of institution of the high-salt diet [ 5 ] . The pathology is identical to human hypertensive renal disease and consists of arteriolosclerosis, glomerulosclerosis, and interstitial scarring with tubular cell dropout.
The role of the Fas/FasL pathway in human hypertensive nephrosclerosis remains to be determined.
While other animal models of hypertension can be employed to study the pathogenesis of hypertension, because of the rapid and reproducible development of renal failure, S rats provide a unique means to investigate the pathogenesis of hypertensive nephrosclerosis.
The pronounced increases in Fas and FasL expression and activation of this pathway by the third week of study also correlated with previous evidence that documented irreversibility of the renal injury if the hypertension was not corrected by this time [ 5 ] . These data supported the view that the Fas/FasL pathway promoted nephrosclerosis in this model.
Recent evidence suggests that apoptosis is involved in several pathological processes in the lung [ 30 31 32 ] and kidney [ 33 34 35 36 37 ] . Using the Dahl/Rapp salt-sensitive (S) rat, which develops hypertensive nephrosclerosis that resembles the human disease process [ 5 ] , this laboratory demonstrated an early and inappropriate apoptotic process that occurred in both glomerular and tubular compartments of the kidneys and correlated with the decline in glomerular filtration rate.
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