Words similar to ncor

Example sentences for: ncor

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Recent results suggest that CAR can interact with NCoR or SMRT in the presence of inverse agonists [ 24 ] , although such interactions appear much weaker than those of other receptors.
RAR/RXR binding to nuclear receptor corepressors such as NCoR and SMRT in the absence of ligand inhibits activation of RA responsive genes [ 3 4 ] . Ligand binding displaces the repressors and recruits coactivator proteins such as CBP which have histone acetyltransferase activity [ 5 ] . Histone acetylation allows for chromatin unwinding and transcriptional initiation of target gene expression [ 6 ] .
The RARα amino terminus is not known to interact with CBP or its associated factor PCAF [ 5 18 ] . Additionally, RARs bind to the interaction domains of repressor proteins such as NCoR via region D of the receptor rather than the amino terminus [ 4 ] . Despite the lack of obvious interaction of the RAR amino terminus with nuclear receptor cofactors, the S77A mutation may alter the three dimensional structure of the receptor.
In the absence of cognate hormone, several nuclear receptors actively repress transcription of target genes via interactions with the nuclear receptor corepressors SMRT and NCoR.
NCoR, nuclear receptor co-repressor