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Example sentences for: nc-
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or with mAb NC-1 [ 20 21 ] . For coating with CAP, a solution of CAP (100 μl; 10 μg/ml in 0.05 M acetate pH 6.0) was added to the wells.
The mouse monoclonal antibody (mAb), NC-1, raised against the gp41 six/helix bundle from HIV-1 IIIB was prepared as described [ 43 ] and shown to react also with six-helix bundles from HIV-1 BaL [ 37 ] . Rabbit antibodies against the gp41 six-helix bundle and against HIV-1 IIIB gp120 were prepared as described [ 44 45 ] . The latter antibodies were shown to crossreact with HIV-1 BaL gp120 [ 37 ] . Rabbit antibodies against HIV-1 tat as well as recombinant HIV-1 IIIB gp120 and biotinylated soluble CD4 (sCD4) were from ImmunoDiagnostics, Inc., Woburn, MA.
The occupancy of CD4 and coreceptor binding sites by their respective ligands elicits downstream conformational changes in the envelope glycoprotein gp41, rendering it competent for fusion between virus and target cell membranes [ 18 19 40 41 42 43 ] . Shedding of gp120 from virus particles is not required for subsequent membrane fusion events [ 44 ] . The induction of gp41 six-helix bundles, detectable by mAb NC-1, by CAP in the absence of gp120 shedding is consistent with this conclusion.
Thus, 58% of patients affected by bone metastases had significantly increased α LCTX values ( Z score > 2) compared with breast cancer patients without bone metastases (NC- patients) (Fig.
Author 3 SJ developed monoclonal antibody NC-1 and was involved in studies on the gp41 six helix bundles and on synergism between CAP and sCD4 for inhibition of HIV-1 infectivity.
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