Words similar to nadir

Example sentences for: nadir

How can you use “nadir” in a sentence? Here are some example sentences to help you improve your vocabulary:

They knew that the RJR Nabisco-leveraged buyout represented the nadir of that era's financial engineering.
The chemotherapy dose was reduced if, on the previous cycle, the nadir ANC was less than 0.5 × 10 9/liter or if the patient experienced an episode of febrile neutropenia, defined as an ANC of less than 1.0 × 10 9/liter with a temperature of more than 100.
Between August 2000 and December 2003, we enrolled 42 patients infected with HIV who were older than 18 y and on ART; eligibility criteria included CD4 counts of greater than 400 cells/μl on ART with a nadir of no less than 100 cells/μl, ART-mediated suppression (< 500 copies/ml) for more than 6 mo and less than 50 copies/ml at recruitment on any antiretroviral regimen.
Finally, we assessed the importance of first-cycle nadir ANC as a predictor of subsequent episodes of febrile neutropenia and of reduced dose intensity (not more than 85% of planned dose intensity) by comparing the proportion of observed events in patients grouped by first-cycle nadir ANC ranges.
A neutropenia-related event was defined similarly to that in the study by Silber and colleagues [ 1 ] : a nadir ANC of 0.5 × 10 9/liter or less, a neutropenia-related dose reduction of 15% or more of the planned dose of any agent, a neutropenia-related dose delay of 7 days or more, or a febrile-neutropenic episode.