Example sentences for: nadir

How can you use “nadir” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The chemotherapy dose was reduced if, on the previous cycle, the nadir ANC was less than 0.5 × 10 9/liter or if the patient experienced an episode of febrile neutropenia, defined as an ANC of less than 1.0 × 10 9/liter with a temperature of more than 100.

  • The nadir for the Clandestine Service was in 1995, when only 25 trainees became new officers.

  • 3. Periprocedural infarction (events occurring during or within 24 hours of percutaneous coronary intervention): CK-MB level ≥ 3 × ULN and >50% above prior nadir value.

  • McCain's nadir came when Bush cleverly asked Orrin Hatch to explain why Republicans oppose McCain's campaign-finance-reform plan.

  • Filgrastim (recombinant methionyl human granulocyte colony-stimulating factor) has been shown to reduce the depth of the nadir ANC, shorten the duration of neutropenia, and reduce the risk of febrile neutropenia [ 3 ] , thereby maintaining chemotherapy dose [ 4 5 ] . Many patients with early-stage breast cancer do not receive the full chemotherapy dose intensity recommended in conventional adjuvant chemotherapy regimens [ 6 7 8 ] . Neutropenia is the primary reason for chemotherapy dose delays and reductions [ 1 6 7 ] .


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