Example sentences for: n-c
How can you use “n-c” in a sentence? Here are some example sentences to help you improve your vocabulary:
6Ashows, a synthetic β-box peptide competed for binding to N-CoR, albeit somewhat less efficiently than native GRIP1 NR box 2. Similar results were obtained in competition experiments that used GST-GRIP1 instead of GST-N-CoR (data not shown).
Thus, N-CoR and SMRT and their associated HDACs are excellent candidates to explain some of the differential behaviors of the ER isoforms.
A mutation (PL T IRML>PL L IRML) that restores the LXXLL consensus increases ERβ binding to N-CoR and permits ERα to bind to N-CoR in the presence of estrogens in mammalian two-hybrid assays.
Other NR coactivators include TRAP220 [ 7 ] , which is part of a larger complex (TRAP/DRIP/SMCC/mediator) that contacts the basal transcription machinery and PGC-1 [ 8 ] , a cold inducible coactivator that binds CBP and SRC-1 and proteins involved in RNA processing [ 9 ] . NR corepressors include NR corepressor (N-CoR) and silencing mediator of retinoid and thyroid responsive transcription (SMRT) [ 4 ] . Both N-CoR and SMRT repress transcription, at least in part, by binding to histone de-acetylases (HDACs) either directly or indirectly through other corepressor complex components.
Thus, N-CoR (2322-2453) is present in molar excess over N-CoR (1944-2453).
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