Example sentences for: n-c

How can you use “n-c” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To examine interactions between ERβ and N-CoR in mammalian cells we performed two-hybrid assays using a GAL4 DBD/N-CoR C-terminus fusion protein as bait and a VP16-ERβ LBD fusion as the prey.

  • NR interactions with N-CoR are usually mediated by a hydrophobic cleft that spans residues from H3 and H5 and includes residues that lie under H12 in the liganded configuration [ 4 17 ] . These interactions are either independent of, or inhibited by, NR H12 [ 17 39 42 ] . By contrast, NR interactions with coactivators are mediated by residues from the upper part of H3-H5 and also require H12 itself [ 18 ] . Fig.

  • Agonist Dependent ERβ Interactions with N-CoR and SMRT

  • Thus, ERβ interactions with N-CoR are dependent on the AF-2 surface (including H12) and, in this regard, resemble those of ERβ and GRIP1.

  • Since ERβ bound N-CoR and SMRT in the presence of estrogens, we investigated the possible involvement of corepressors in the actions of agonist-bound ERβ in vivo . To perform this experiment, we examined the effect of the HDAC inhibitor trichostatin A (TSA) on ERβ activity in transiently transfected HeLa cells.


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