Words similar to myristoyl
Example sentences for: myristoyl
How can you use “myristoyl” in a sentence? Here are some example sentences to help you improve your vocabulary:
Based on the differing extents to which the myristoyl group-accepting sequence improved the ability of the different mutant versions of Boi1-PH to function, we propose that the main role of binding to PS is to promote association with membrane and that binding to PIP 2 plays some additional important role.
If specific binding to PIP 2 (and/or to some other phosphatidylinositide, such as PI4P) is critical for Boi1 function, then how could fusion to a myristoyl group-accepting sequence (i.e.
, to a membrane-localization tag) improve the function of mutant versions of Boi1-PH that are impaired in the ability to bind PIP 2 ? One possibility is that each of these mutant versions of Boi1 retains at least a slight affinity for PIP 2 and that the myristoyl group causes these mutant PH domains to be apposed close enough to the lipid bilayer to enable the residual PIP 2 -binding activity to now be sufficient for binding to PIP 2 . We speculate that, just as binding to PS may serve to position the PH domain of wild-type Boi1 near the plasma membrane in a manner that facilitates binding to PIP 2 , the myristoyl group may help to situate the PH domain of the mutant versions of Boi1-PH at the plasma membrane in a manner that facilitates binding to PIP 2 .
This finding is consistent with the possibility that the ability of the myristoyl group to improve function to a version of Boi1 that is impaired in the ability to bind phospholipids may depend on the myristoyl group being near enough to the PH domain to be able to promote a close association with membrane of specifically the PH domain portion of the protein.
Amino-acid substitutions that diminish binding to PS and PIP 2 impair Boi1 function, and fusion to a myristoyl group-accepting sequence improves the ability of these mutant versions of Boi1-PH to function, suggesting that binding to phospholipids is important for Boi1 action.
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