Words similar to myristoyl
Example sentences for: myristoyl
How can you use “myristoyl” in a sentence? Here are some example sentences to help you improve your vocabulary:
Amino-acid substitutions that diminish binding to PS and PIP 2 impair Boi1 function, and fusion to a myristoyl group-accepting sequence improves the ability of these mutant versions of Boi1-PH to function, suggesting that binding to phospholipids is important for Boi1 action.
The myristoyl group-accepting sequence did not completely restore function to the KK and KKTK versions of Boi1-PH, however, raising the possibility that, rather than simply promoting general association with membrane, one role of binding to PIP 2 may be to regulate some other behavior of Boi1 (e.g.
This finding is consistent with the possibility that the ability of the myristoyl group to improve function to a version of Boi1 that is impaired in the ability to bind phospholipids may depend on the myristoyl group being near enough to the PH domain to be able to promote a close association with membrane of specifically the PH domain portion of the protein.
Fusion to a myristoyl group-accepting sequence appeared to completely restore function to Boi1-PH(TK), consistent with the possibility that the TK substitutions may affect primarily association with membrane.
, to a membrane-localization tag) improve the function of mutant versions of Boi1-PH that are impaired in the ability to bind PIP 2 ? One possibility is that each of these mutant versions of Boi1 retains at least a slight affinity for PIP 2 and that the myristoyl group causes these mutant PH domains to be apposed close enough to the lipid bilayer to enable the residual PIP 2 -binding activity to now be sufficient for binding to PIP 2 . We speculate that, just as binding to PS may serve to position the PH domain of wild-type Boi1 near the plasma membrane in a manner that facilitates binding to PIP 2 , the myristoyl group may help to situate the PH domain of the mutant versions of Boi1-PH at the plasma membrane in a manner that facilitates binding to PIP 2 .
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