Words similar to myristoyl
Example sentences for: myristoyl
How can you use “myristoyl” in a sentence? Here are some example sentences to help you improve your vocabulary:
The myristoyl group-accepting sequence did not completely restore function to the KK and KKTK versions of Boi1-PH, however, raising the possibility that, rather than simply promoting general association with membrane, one role of binding to PIP 2 may be to regulate some other behavior of Boi1 (e.g.
, to a membrane-localization tag) improve the function of mutant versions of Boi1-PH that are impaired in the ability to bind PIP 2 ? One possibility is that each of these mutant versions of Boi1 retains at least a slight affinity for PIP 2 and that the myristoyl group causes these mutant PH domains to be apposed close enough to the lipid bilayer to enable the residual PIP 2 -binding activity to now be sufficient for binding to PIP 2 . We speculate that, just as binding to PS may serve to position the PH domain of wild-type Boi1 near the plasma membrane in a manner that facilitates binding to PIP 2 , the myristoyl group may help to situate the PH domain of the mutant versions of Boi1-PH at the plasma membrane in a manner that facilitates binding to PIP 2 .
Fusion to a myristoyl group-accepting sequence appeared to completely restore function to Boi1-PH(TK), consistent with the possibility that the TK substitutions may affect primarily association with membrane.
This finding is consistent with the possibility that the ability of the myristoyl group to improve function to a version of Boi1 that is impaired in the ability to bind phospholipids may depend on the myristoyl group being near enough to the PH domain to be able to promote a close association with membrane of specifically the PH domain portion of the protein.
If specific binding to PIP 2 (and/or to some other phosphatidylinositide, such as PI4P) is critical for Boi1 function, then how could fusion to a myristoyl group-accepting sequence (i.e.
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