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Example sentences for: murinised

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The Ad Adapt mhAB encodes for a murinised form of the human ATF-BPTI [ 21 ] . In this construct the mhAB, is preceded by the native secretion signal peptide of the human urokinase.
The murinised version of ATF-BPTI differs by four amino acids from the human version It was shown to bind to the rat receptor and to inhibit plasmin activity in a rat model [ 21 ] . BPTI (commercialised as aprotinin) is a serine protease inhibitor prepared from bovine lung tissue which dose dependently inhibits human trypsin, plasmin and kallikrein.
mhATF: Murinised human ATF
The plasmid pAdapt Luc, pAdpat LacZ, pAdapt hEndo and pAdapt mhAB encoding respectively for the luciferase, β-galactosidase, human endostatine and murinised human ATF-BPTI genes were constructed as described previously [ 23 ] . The different genes are under the control of the cytomegalovirus (CMV) immediate-early promotor and terminated by the simian virus (SV40) late poly(A) signal.
The murinised ATF-BPTI (mhAB) plasmid was constructed by an identical procedure, using the (Tyr22, Arg27,29,30) uPA mutant cDNA as starting sequence [ 33 ] .