Words similar to murine
Example sentences for: murine
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MBT-2 murine urothelial cancer cells and their culture conditions for passage were previously described.
Type 1 diabetes mellitus (T1DM) is a T cell-mediated autoimmune disease characterized by lymphocytic infiltration of the pancreatic islets of Langerhans with subsequent destruction of the insulin-producing beta cells [ 1 ] . Non-obese diabetic (NOD) female mice, a murine model for T1DM, spontaneously develop diabetes by 30 weeks-of-age, with infiltrating cells appearing around the pancreatic islets as early as at 3-4 weeks-of-age [ 2 ] .
The bone morphogenetic protein (BMP) family including ligands, receptors, and binding proteins, has emerged as a central player in ovary physiology and female fertility [ 1 ] . The BMPs represent a large subclass of the transforming growth factor-β (TGF-β) surperfamily of ligands whose biological responses are mediated by Ser/Thr kinase receptors via the Smad-signaling molecules [ 2 ] . The mRNAs encoding several BMP family members have been identified in the murine ovary, including the ligands, BMP-2 [ 3 ] , BMP-3 [ 3 ] , BMP-3b [ 3 ] , BMP-4 [ 4 ] , BMP-6 [ 5 ] , BMP-7 [ 4 ] , BMP-15 [ 6 7 8 ] , the BMP receptors, BMPR-IA, BMPR-IB and BMPR-II [ 4 ] and the BMP binding protein, follistatin (FS) [ 9 ] . In the murine, BMP-4 and -7 mRNA have been identified in the theca interstitial cells [ 4 ] , BMP-6 and -15 in oocytes [ 5 6 7 8 ] , BMPR-IA, BMPR-IB and BMPR-II in oocytes and granulosa cells (GCs) [ 4 ] , and FS in granulosa and lutein cells [ 9 10 ] .
To test whether the Hh agonist could interact with Smo in vitro , we transiently overexpressed murine Smo, murine Ptc, rat β2-adrenergic receptor and GFP in 293T cells, harvested membranes and performed a filtration membrane-binding assay in a 96-well plate with [ 3H]-Hh-Ag 1.5 added at 2 nM.
The murine ATM was found significantly different in size, although the ATM knockout mice recapitulate the phenotypic features of A-T patients [ 36 ] . This species difference may be important in interpreting the data from human cells and from murine cells.